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Evaluating the Efficacy and Cost-Effectiveness of Plasmapheresis and Intravenous Immunoglobulin in Acute Guillain-Barre Syndrome Management in Emergency Departments.
Cureus
October 2024
Internal Medicine, Mardan Medical Complex, Mardan, PAK.
Background: Guillain-Barre Syndrome (GBS) is a severe autoimmune neuropathy that has to be treated quickly and efficiently in emergency situations, when both cost and effectiveness are vital.
Objective: To compare the clinical outcomes and cost-effectiveness of plasmapheresis and intravenous immunoglobulin (IVIG) in managing acute GBS in emergency departments.
Methodology: A prospective observational study conducted from January to December 2023 evaluated the treatment of adults with acute GBS using IVIG or plasmapheresis.
Convalescent plasma therapy for COVID-19 - Donor selection strategies and establishment of a plasma bank.
New Microbes New Infect
December 2024
Meilahti Vaccine Research Center, MeVac, Department of Infectious Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Background: Early in the COVID-19 pandemic, convalescent plasma (CP) emerged as a potentially effective treatment neutralising SARS-CoV-2. Early CP therapy with high neutralising antibody (NAb) titre may benefit COVID-19 outpatients and, in sufficient quantities even some hospitalised patients. This study details the process of setting up a CP bank, containing high- and low-titre CP for a clinical trial.
View Article and Find Full Text PDFTherapeutic Apheresis in Pediatric Renal Transplant Recipients.
Exp Clin Transplant
October 2024
From the Urology and Nephrology Research Center, Shahidbeheshti of Medical Sciences, Tehran, Iran.
Clear guidelines for therapeutic apheresis in children after renal transplant do not exist. This article reviews the current experiences with therapeutic apheresis in pediatric transplant recipients. The ideal characteristics of removable substances should have all of the following criteria for an effective therapeutic apheresis: large molecular weight (>15 kDa), prolonged half-life, rapid elimination from the plasma, high intravascular distribution, and low turnover rate.
View Article and Find Full Text PDFComparison of efficacy and safety of different anticoagulation regimens in plasma exchange: A systematic review and meta-analysis.
PLoS One
October 2024
Department of Nephrology and Institute of Nephrology, Sichuan Clinical Research Centre for Kidney Diseases, School of Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Article Synopsis
- - The study investigates the effectiveness and safety of various anticoagulation methods used during plasma exchange (PE), noting that current methods can lead to clotting issues that waste nursing resources.
- - A systematic review included 7 studies involving over 1,600 patients, finding that unfractionated heparin (UFH) was better than saline for preventing clotting but showed similar results to low-molecular-weight heparin (LMWH) and regional citrate anticoagulation (RCA).
- - The findings suggest that while current anticoagulation methods are generally effective, there's a risk of longer post-treatment aPTT (a clotting test) and lower platelet counts with UFH; however, more research is needed for
Necrotizing Pancreatitis Due to Very High Triglyceride Level: A Case Report.
Cureus
September 2024
Internal Medicine, NYC Health + Hospitals/Queens (Queens Hospital Center), New York, USA.
In the United States, acute pancreatitis is one of the most common gastrointestinal conditions that results in hospital admission. Necrotizing pancreatitis is a form of acute pancreatitis that can lead to various local and systemic complications. It is also associated with a high risk of mortality and morbidity without prompt intervention.
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