Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4103/0028-3886.198271 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Investigating Neurometabolite Changes in Response to Median Nerve Stimulation.
Brain Behav
January 2025
School of Psychology, University of Nottingham University Park, Nottingham, UK.
Background: Rhythmic median nerve stimulation (MNS) at 10 Hz has been shown to cause a substantial reduction in tic frequency in individuals with Tourette syndrome. The mechanism of action is currently unknown but is hypothesized to involve entrainment of oscillations within the sensorimotor cortex.
Objective: We used functional magnetic resonance spectroscopy (fMRS) to explore the dynamic effects of MNS on neurometabolite concentrations.
Pimozide and Adipic Acid: A New Multicomponent Crystalline Entity for Improved Pharmaceutical Behavior.
Molecules
November 2024
Department of Chemistry, Physical Chemistry Section & C.S.G.I. (Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase), University of Pavia, Via Taramelli 16, 27100 Pavia, Italy.
Pimozide is a first-generation antipsychotic used in the treatment of schizophrenia, Gilles de la Tourette syndrome, and other chronic psychoses. Its in vivo efficacy is limited by poor solubility and consequent poor bioavailability. Therefore, adipic acid was used as a coformer for the preparation of a binary product with improved pharmaceutical properties.
View Article and Find Full Text PDFClosed-loop systems for deep brain stimulation to treat neuropsychiatric disorders.
Expert Rev Med Devices
December 2024
Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, ON, Canada.
Introduction: A closed-loop or feedback-control system is a process which considers the system's output in order to automatically adjust the input. Compared to a traditional open-loop system, a closed-loop system allows for a higher degree of accuracy with minimal human intervention. Novel methods of closed loop 'adaptive' deep brain stimulation DBS (aDBS) are being developed.
View Article and Find Full Text PDFRole of Neurosurgical Interventions in the Treatment of Movement Disorders Like Parkinson's Disease, Dystonia, and Tourette Syndrome.
Cureus
October 2024
Medicine, Ivane Javakhishvili Tbilisi State University, Tbilisi, GEO.
Article Synopsis
- The article reviews surgical treatments for movement disorders like Tourette syndrome, dystonia, and Parkinson's disease, focusing on their benefits and future research directions.
- It emphasizes advanced therapies, including non-invasive neuromodulation and closed-loop deep brain stimulation, as potential primary options for treating these conditions.
- The study advocates for ongoing clinical trials and research to refine these therapies, particularly for dystonia, by exploring new brain stimulation methods and gene therapy advancements.
Pain in Tourette Syndrome: A Comprehensive Review.
J Child Adolesc Psychopharmacol
November 2024
Neurology and Neurosurgery, Medical Director, Movement Disorders Neuromodulation & Brain Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Article Synopsis
- Recent surveys indicate that a significant percentage (47%-60%) of individuals with Tourette syndrome (TS) experience pain, suggesting a need for systematic investigation into how pain affects this population.
- The article identifies different types of pain associated with TS, including tic-related pain and suppression-related pain, while highlighting altered sensory processing as a potential underlying cause.
- Current clinical measures often overlook pain in TS, indicating a gap in research; future studies should focus on understanding pain mechanisms and developing effective assessment methods and treatments.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!