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Mid-life anti-inflammatory metabolites are inversely associated with long-term cardiovascular disease events.
EBioMedicine
January 2025
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Heart and Vascular Institute, UPMC, Pittsburgh, PA, USA.
Background: Preclinical data have shown that low levels of metabolites with anti-inflammatory properties may impact metabolic disease processes. However, the association between mid-life levels of such metabolites and long-term ASCVD risk is not known.
Methods: We characterised the plasma metabolomic profile (1228 metabolites) of 1852 participants (58.
Biomarkers of glucose-insulin homeostasis and incident type 2 diabetes and cardiovascular disease: results from the Vitamin D and Omega-3 trial.
Cardiovasc Diabetol
November 2024
Division of Preventive Medicine, Center for Lipid Metabolomics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Background: Dysglycemia and insulin resistance increase type 2 diabetes (T2D) and cardiovascular disease (CVD) risk, yet associations with specific glucose-insulin homeostatic biomarkers have been inconsistent. Vitamin D and marine omega-3 fatty acids (n-3 FA) may improve insulin resistance. We sought to examine the association between baseline levels of insulin, C-peptide, HbA1c, and a novel insulin resistance score (IRS) with incident cardiometabolic diseases, and whether randomized vitamin D or n-3 FA modify these associations.
View Article and Find Full Text PDFAssociation of chronic neutrophil activation with risk of mortality.
PLoS One
July 2023
MDVIP, Boca Raton, Florida, United States of America.
Background: Levels of free myeloperoxidase (MPO), a cardiovascular risk marker, have been reported to decline with standard care. Whether such declines signify decreased risk of mortality remains unknown.
Design: Cox proportional hazard models were generated using data from a retrospective cohort study of prospectively collected measures.
Prevalence of Antiphospholipid Antibodies and Association With Incident Cardiovascular Events.
JAMA Netw Open
April 2023
Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
Importance: The prevalence of antiphospholipid antibodies (aPL) and their association with future atherosclerotic cardiovascular disease (ASCVD) risk has yet to be thoroughly investigated.
Objective: To determine the association between measurements of aPL at a single time point and ASCVD risk in a diverse population.
Design, Setting, And Participants: This cohort study measured 8 aPL (anticardiolipin [aCL] IgG/IgM/IgA, anti-beta-2 glycoprotein I [aβ2GPI] IgG/IgM/IgA, and antiphosphatidylserine/prothrombin [aPS/PT] IgG/IgM) by solid-phase assays in plasma from participants of the Dallas Heart Study (DHS) phase 2, a multiethnic, population-based cohort study.
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