Calcinosis universalis lesions in scleroderma.

Oral Surg Oral Med Oral Pathol

Published: August 1978

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http://dx.doi.org/10.1016/0030-4220(78)90210-4DOI Listing

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Article Synopsis
  • Medical literature highlights complications from cosmetic procedures like silicone injections, with rising cases of hypercalcemia attributed to granulomatous inflammation against silicone as a foreign body.
  • A case report details a 44-year-old male with a history of HIV and chronic kidney disease, who developed calcinosis universalis linked to silicone injections, presenting various lab results and imaging findings during multiple hospital visits.
  • Initial treatment involved IV fluids and pamidronate to lower calcium levels, followed by an outpatient regimen including denosumab, mirroring findings in existing literature on silicone-induced hypercalcemia.
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Calcinosis universalis accompanied by symptomatic systemic sclerosis.

Australas J Dermatol

March 2024

Department of Dermatology, Institute of Dermatology and Venereology, Fujian Dermatology and Venereology Research Institute, Key Laboratory of Skin Cancer of Fujian Higher Education Institutions, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Calcinosis cutis is represented by the deposition of insoluble calcium salts in the skin and subcutaneous tissue. Calcinosis can lead to repeated episodes of local inflammation and repeated infections, resulting in pain and functional disability, and even death. Here, we present a case of a patient with SSc who experienced calcinosis universalis and eventually died from recurrent infections at the sacrococcygeal calcification.

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