A 3-year-old boy referred for persistent tongue bleeding was diagnosed with a rare self-mutilating disease that had also affected his lip and fingers. He underwent multiple odontectomy and partial glossectomy and continues to undergo behavior therapy and on-demand splints and restraints. He has stopped self-biting and has gained appetite and weight. Lesch-Nyhan Syndrome can cause significant morbidity including self-inflicted oral hemorrhage and emergent measures are not easily decided. The long-term management of its neurobehavioral symptoms is problematic and multidisciplinary, and health providers remain challenged to find the best treatment, prolong lifespan and improve quality of life within their respective contexts.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216325 | PMC |
| http://dx.doi.org/10.12669/pjms.326.12088 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Increasing Bone Regeneration in Maxillary Sinus Augmentation Using Platelet-rich Fibrin: An Interventional Pre-Post Study.
J Contemp Dent Pract
September 2024
Department of Pediatrics Dentistry and Orthodontics, Faculty Odonto-Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam.
Aim: This study aimed to evaluate the impact of a combination of immediate implant placement with maxillary sinus augmentation (MSA) solely using platelet-rich fibrin (PRF) on guided bone regeneration.
Materials And Methods: An interventional before-after (pre-post) study design was used with 30 dental patients (≥18 years of age; 14 males and 16 females) with initial bone heights ranging between 4 and 6 mm. Following the general check-up and the creation of a study model, the planned implant location demonstrated an external right maxilla diameter of more than 5 mm, thereby validating the cone-beam computed tomography (CBCT) radiograph.
Gingival Metastasis After Surgery for Early-Stage Lung Adenocarcinoma.
Ann Thorac Surg Short Rep
December 2024
Department of Thoracic Surgery, Japanese Red Cross Osaka Hospital, Osaka, Japan.
A 69-year-old male patient underwent a left upper lung lobectomy and nodal dissection for left upper lung adenocarcinoma. His pathologic stage was pT2aN0M0, stage 1B. He received oral tegafur/uracil for adjuvant chemotherapy and visited our hospital every 2 months.
View Article and Find Full Text PDFA common data model for oral anticoagulants-related risk of spontaneous intracranial hemorrhage.
J Clin Neurosci
January 2025
Deparment of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, 101, Daehak-ro Jongno-gu, Seoul 03080, Republic of Korea. Electronic address:
Spontaneous intracranial hemorrhage (sICH) is a major complication associated with oral anticoagulation which results in a high mortality rate, and the incidence of anticoagulant-induced sICH has increased markedly, so it is necessary to investigate the risk of anticoagulation-related sICH in a real-world setting. We aimed to investigate the incidence and risk factors of oral anticoagulant-related sICH using a common data model (CDM), and to determine whether a clinical study using the CDM would be comparable to conventional studies. After converting the various clinical codes of 12,821 patients taking oral anticoagulants, such as warfarin and non-vitamin K antagonist oral anticoagulants (NOACs), into the Observational Medical Outcomes Partnership (OMOP) CDM format, we analyzed the incidence and risk factors of sICH.
View Article and Find Full Text PDFRepurposing renin‐angiotensin system‐targeting medications for treatment of cerebral amyloid angiopathy and associated cognitive‐behavioral deficits in Tg‐SwDI mice.
Alzheimers Dement
December 2024
Nova Southeastern University, Fort Lauderdale, FL, USA
Background: Cerebral amyloid angiopathy (CAA), the accumulation of amyloid proteins in the cerebral vasculature, increases the risk of stroke and vascular cognitive impairment and dementia (VCID). Not only is there no treatment for CAA, but the condition is also highly comorbid with Alzheimer’s disease (AD), and its presence may serve as a contraindication to treating patients with anti‐amyloid therapies due to an increased risk of hemorrhage and edema. Therefore, it is crucial to identify novel treatments for individuals with CAA.
View Article and Find Full Text PDFConcurrent Bacteremia and Severe Fever With Thrombocytopenia Syndrome: A Report of Two Cases.
Cureus
December 2024
Department of Emergency and Critical Care Medicine, National Hospital Organization Nagasaki Medical Center, Nagasaki, JPN.
Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral hemorrhagic fever caused by the severe fever with thrombocytopenia syndrome virus (SFTSV). This virus, which is transmitted through ticks, is prevalent in Asian countries, including Japan. This report describes two rare cases of SFTS with concurrent bacteremia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!