Iron Uptake Analysis in a Set of Clinical Isolates of .

Front Microbiol

Environmental Protection Department, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas Granada, Spain.

Published: December 2016

strains are frequent inhabitants of soil and aquatic niches and they are occasionally isolated from hospital environments. As the available iron sources in human tissues, edaphic, and aquatic niches are different, we have analyzed iron-uptake related genes in different strains that were isolated from all these environments. We found that these isolates can be grouped into different clades according to the genetics of siderophore biosynthesis and recycling. The pyoverdine locus of the six clinical isolates that have so far been completely sequenced, are not closely related; three strains ( HB13667, HB3267, and NBRC14164T) are grouped in Clade I and the other three in Clade II, suggesting possible different origins and evolution. In one clinical strain, HB4184, the production of siderophores is induced under high osmolarity conditions. The pyoverdine locus in this strain is closely related to that of strain HB001 which was isolated from sandy shore soil of the Yellow Sea in Korean marine sand, suggesting their possible origin, and evolution. The acquisition of two unique TonB-dependent transporters for xenosiderophore acquisition, similar to those existing in the opportunistic pathogen PAO, is an interesting adaptation trait of the clinical strain H8234 that may confer adaptive advantages under low iron availability conditions.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187384PMC
http://dx.doi.org/10.3389/fmicb.2016.02100DOI Listing

Publication Analysis

Top Keywords

clinical isolates
8
aquatic niches
8
pyoverdine locus
8
clinical strain
8
iron uptake
4
uptake analysis
4
analysis set
4
clinical
4
set clinical
4
isolates strains
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!