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Prenatal Exposure to DEHP Induces Premature Reproductive Senescence in Male Mice. | LitMetric

AI Article Synopsis

  • - *Di-(2-ethylhexyl) phthalate (DEHP) is a commonly used chemical that disrupts hormonal functions, and a study was conducted to see if prenatal exposure leads to early reproductive issues in male mice.* - *Pregnant female mice were exposed to varying doses of DEHP, and while the offspring did not show immediate physical health problems, significant reproductive dysfunction was observed as they aged, particularly in those exposed to the highest doses.* - *By 19 months, a high percentage of DEHP-exposed mice became infertile, showing hormonal imbalances and various testicular abnormalities, indicating that prenatal DEHP exposure causes early reproductive aging in male mice.*

Article Abstract

Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used phthalate, and it is an endocrine-disrupting chemical. This study tested a hypothesis that prenatal exposure to DEHP lays the foundation for premature gonadal dysfunction and subsequent reproductive senescence in male mice. Pregnant female CD-1 mice were orally dosed with vehicle control (tocopherol-stripped corn oil) or with 20 μg/kg/day, 200 μg/kg/day, 500 mg/kg/day, or 750 mg/kg/day of DEHP from gestational day 11 to birth. Overall, the prenatal DEHP exposure did not cause any overt physical health problems in male offspring, as no significant differences in their body nor gonadal weight were seen up to the age of 23 months. However, an age- and dose-dependent gonadal dysfunction was observed. As early as 7 months of age, the 750 mg/kg/day group of mice exhibited significantly reduced fertility. At 19 months of age, 86% of the 750 mg/kg/day mice became infertile, whereas only 25% of the control mice were infertile. At this age, all of the DEHP-exposed mice had lower serum testosterone levels, higher serum estradiol levels, and higher LH levels compared with control mice. Histological evaluations showed that mice prenatally exposed to DEHP displayed a wide array of gonadal and epididymal abnormalities such as increased germ cell apoptosis, degenerative seminiferous tubules, oligozoospermia, asthenozoospermia, and teratozoospermia in comparison to age-matching control mice. In summary, this study shows that prenatal exposure to DEHP induces premature reproductive senescence in male mice.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075616PMC
http://dx.doi.org/10.1093/toxsci/kfw248DOI Listing

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