A report from the Health Protection Agency last month revealed that 3,010 men who have sex with men (MSM) were diagnosed with HIV in 2011 - the highest number in any year since the AIDS epidemic began in 1981.
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On the importance of assessing topological convergence in Bayesian phylogenetic inference.
Virus Evol
October 2024
Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Modern phylogenetics research is often performed within a Bayesian framework, using sampling algorithms such as Markov chain Monte Carlo (MCMC) to approximate the posterior distribution. These algorithms require careful evaluation of the quality of the generated samples. Within the field of phylogenetics, one frequently adopted diagnostic approach is to evaluate the and to investigate trace graphs of the sampled parameters.
View Article and Find Full Text PDFSafety and immunogenicity of a modified mRNA-lipid nanoparticle vaccine candidate against COVID-19: Results from a phase 1, dose-escalation study.
Hum Vaccin Immunother
December 2024
GSK, Wavre, Belgium.
This phase 1, open-label, dose-escalation, multi-center study (NCT05477186) assessed the safety and immunogenicity of a booster dose of an mRNA COVID-19 vaccine (CV0501) encoding the SARS-CoV-2 Omicron BA.1 spike protein. Participants aged ≥ 18 years previously vaccinated with ≥ 2 doses of an mRNA COVID-19 vaccine received CV0501 doses ranging from 12 to 200 μg.
View Article and Find Full Text PDFMental health problems in pregnant and postpartum women living with HIV in sub-Saharan Africa: Systematic review and meta-analysis protocol.
PLoS One
October 2024
Centre for Evidence Synthesis and Policy, University of Ghana, Legon, Accra, Ghana.
Article Synopsis
- Limited data on mental health issues among pregnant and postpartum women living with HIV in sub-Saharan Africa hampers the development of effective interventions.
- This systematic review will gather and analyze various studies to assess the mental health burden and its determinants in this specific population across SSA.
- The research will involve comprehensive database searches, independent study selections and data extraction by reviewers, and assessment of bias in studies to ensure accurate results.
Cohort profile update: the Johns Hopkins HIV clinical cohort, 1989-2023.
Eur J Epidemiol
September 2024
Johns Hopkins School of Medicine, Baltimore, MD, USA.
The Johns Hopkins HIV Clinical Cohort, established in 1989, links comprehensive, longitudinal clinical data for adults with HIV receiving care in the Johns Hopkins John G. Bartlett Specialty Practice in Baltimore, Maryland, USA, to aid in understanding HIV care and treatment outcomes. Data include demographics, laboratory results, inpatient and outpatient visit information and clinical diagnoses, and prescribed and dispensed medications abstracted from medical records.
View Article and Find Full Text PDFOn the importance of assessing topological convergence in Bayesian phylogenetic inference.
ArXiv
August 2024
Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Modern phylogenetics research is often performed within a Bayesian framework, using sampling algorithms such as Markov chain Monte Carlo (MCMC) to approximate the posterior distribution. These algorithms require careful evaluation of the quality of the generated samples. Within the field of phylogenetics, one frequently adopted diagnostic approach is to evaluate the (ESS) and to investigate trace graphs of the sampled parameters.
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