AI Article Synopsis
- A study on inbred mice shows a gene linked to maternal instincts, particularly a tendency for females to lose pups.
- QTL mapping identified a significant gene on chromosome 16, named nurturing ability QTL 3 (Naq3), that correlates with this issue.
- Most mothers who lost their litters had the RR/Sgn allele at Naq3, leading researchers to suggest Mapk1, Kalrn, and Vps8 as potential candidate genes influencing this trait.
Article Abstract
Females of the inbred mouse strain RR/Sgn have an apparent tendency to lose pups during rearing. To identify genes underlying this abnormal maternal phenotype, we performed quantitative trait loci (QTL) mapping in 349 (C57BL/6 J × RR/Sgn) F × RR/Sgn backcross mice and identified one significant and one suggestive QTL on chromosomes 16 and 4, respectively. We assigned the gene symbol nurturing ability QTL 3 (Naq3) to the QTL on chromosome 16. Twenty of the 21 mothers who lost entire litters were homozygous for RR/Sgn allele at Naq3; i.e., the significant association of Naq3 with pup loss was further confirmed by binomial tests. We tentatively propose that Mapk1, Kalrn, and Vps8 are potential candidate genes for Naq3.
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| http://dx.doi.org/10.1111/cga.12199 | DOI Listing |
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