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Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin.
FEBS J
May 2020
Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento, Italy.
Protein kinase CK2 is an antiapoptotic cancer-sustaining protein. Curcumin, reported previously as a CK2 inhibitor, is too bulky to be accommodated in the CK2 active site and rapidly degrades in solution generating various ATP-mimetic inhibitors; with a detailed comparative analysis, by means of both protein crystallography and enzymatic inhibition, ferulic acid was identified as the principal curcumin degradation product responsible for CK2 inhibition. The other curcumin derivatives vanillin, feruloylmethane and coniferyl aldehyde are weaker CK2 inhibitors.
View Article and Find Full Text PDFCurcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth.
Sci Rep
February 2018
Laboratory of Tumor Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, 630-0101, Japan.
Curcumin has been reported to exhibit anti-tumorigenic activity; however, since its precise actions remain unclear, its effects are considered to be deceptive. In the present study, we confirmed the anti-tumorigenic effects of curcumin on CML-derived leukemic cells in a xenograft model and in vitro culture system. In vitro pull-down and mass analyses revealed a series of enzymes (carbonyl reductase, glutathione-S-transferase, glyoxalase, etc.
View Article and Find Full Text PDFCurcumin: An Effective or Deceptive Dietary Factor? Challenges for Functional Food Scientists.
J Agric Food Chem
February 2018
College of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan.
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