The palladium(II)-catalyzed β- and γ-alkynylation of amide C(sp )-H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing α-tertiary or α-quaternary carbon centers. The β-methylene C(sp )-H bonds of various carbocyclic rings were also successfully alkynylated.
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| http://dx.doi.org/10.1002/anie.201610426 | DOI Listing |
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