Congenital Plasmodium falciparum Malaria in Washington, DC.

Am J Trop Med Hyg

Division of Pediatric Infectious Diseases, Children's National Medical Center, Washington, District of Columbia.

Published: January 2017

Congenital malaria is rare in the United States, but is an important diagnosis to consider when evaluating febrile infants. Herein, we describe a case of congenital Plasmodium falciparum malaria in a 2-week-old infant born in the United States to a mother who had emigrated from Nigeria 3 months before delivery.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239687PMC
http://dx.doi.org/10.4269/ajtmh.15-0630DOI Listing

Publication Analysis

Top Keywords

congenital plasmodium
8
plasmodium falciparum
8
falciparum malaria
8
united states
8
malaria washington
4
washington congenital
4
congenital malaria
4
malaria rare
4
rare united
4
states diagnosis
4

Similar Publications

Article Synopsis
  • Placental malaria (PM) in the Metti Health Centre study showed high prevalence rates: 34.4% for PM, 24.4% for gestational malaria (GM), and significant issues like maternal anemia (41.7%) and low birth weight (27.8%).
  • Key risk factors identified for GM included recent malaria history, lack of indoor residual spraying, and absence of antenatal care, whereas for PM, recent malaria history and lack of antenatal care were highlighted.
  • The study utilized a cross-sectional design with various diagnostic tools to assess the impact of malaria on pregnancy outcomes among parturient women in Southwest Ethiopia.
View Article and Find Full Text PDF

Congenital Plasmodium vivax in a 3-day-old neonate: a case report.

J Med Case Rep

November 2024

Department of Pediatrics and Neonatal Nursing, School of Nursing and Midwifery, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia.

Background: Congenital malaria is an uncommon clinical infectious disease caused by vertical transmission of parasites from mother to child during pregnancy or delivery and a positive blood smear of malaria in newborns from 24 hours to 7 days of life, associated with a high mortality rate if it is not diagnosed and treated early. We present an unusual case of a 4-day-old boy with Plasmodium vivax malaria from Gondar, Ethiopia, suspected mainly based on a positive maternal history of malaria attacks in the seventh month of gestation and cured with artemether-lumefantrine therapy. The newborn presented with a lack of sucking and a high-grade fever.

View Article and Find Full Text PDF

Teratogenic parasites: disease mechanisms and emerging study models.

Trends Parasitol

December 2024

Department of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Congenital infections are a leading preventable cause of pregnancy complications impacting both mother and fetus. Although advancements have been made in understanding various congenital infections, the mechanisms of parasitic infections during pregnancy remain poorly understood. This review covers the global incidence of three parasites capable of congenital transmission - Trypanosoma cruzi, Plasmodium spp.

View Article and Find Full Text PDF

Introduction: ProC6C is a multi-stage malaria vaccine which includes Circumsporozoite Protein (PfCSP), Pfs48/45 and Pfs230 sequences, designed to elicit functional antibodies that prevent sporozoite invasion of human hepatocytes (PfCSP) and parasite development in mosquitoes (Pfs48/45 and Pfs230). ProC6C formulated on Alhydrogel was evaluated in combination with Matrix-M in a Phase 1 trial in Burkina Faso. The PfCSP antibody responses were assessed for magnitude, specificity, avidity and functionality.

View Article and Find Full Text PDF

Background: Neonatal malaria is defined as the detection of asexual stages of Plasmodium species in the cord blood within the first 28 days of life. It can be congenital or acquired through mosquito bites or blood transfusions. Neonates are generally considered to be relatively protected due to the multiple innate and acquired physiological protective effects present in neonates.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!