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HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology. | LitMetric

AI Article Synopsis

  • - The only biomarker for selecting specific therapy in advanced gastroesophageal adenocarcinoma (GEA) is HER2, but there are currently no comprehensive guidelines for its assessment.
  • - An expert panel aimed to create evidence-based guidelines for HER2 testing, resulting in 11 recommendations that emphasize the importance of assessing HER2 status in all advanced GEA patients before starting therapy.
  • - The guidelines also provide detailed instructions for pathologists on how to properly select tumor specimens, use testing algorithms, and ensure quality assurance in HER2 testing.

Article Abstract

Context: ERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker established for selection of a specific therapy for patients with advanced gastroesophageal adenocarcinoma (GEA). However, there are no comprehensive guidelines for the assessment of HER2 in patients with GEA.

Objectives: To establish an evidence-based guideline for HER2 testing in patients with GEA, to formalize the algorithms for methods to improve the accuracy of HER2 testing while addressing which patients and tumor specimens are appropriate, and to provide guidance on clinical decision making.

Design: The College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology convened an expert panel to conduct a systematic review of the literature to develop an evidence-based guideline with recommendations for optimal HER2 testing in patients with GEA.

Results: The panel is proposing 11 recommendations with strong agreement from the open-comment participants.

Recommendations: The panel recommends that tumor specimen(s) from all patients with advanced GEA, who are candidates for HER2-targeted therapy, should be assessed for HER2 status before the initiation of HER2-targeted therapy. Clinicians should offer combination chemotherapy and a HER2-targeted agent as initial therapy for all patients with HER2-positive advanced GEA. For pathologists, guidance is provided for morphologic selection of neoplastic tissue, testing algorithms, scoring methods, interpretation and reporting of results, and laboratory quality assurance.

Conclusions: This guideline provides specific recommendations for assessment of HER2 in patients with advanced GEA while addressing pertinent technical issues and clinical implications of the results.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272805PMC
http://dx.doi.org/10.1093/ajcp/aqw206DOI Listing

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