Human infants develop language remarkably rapidly and without overt instruction. We argue that the distinctive ontogenesis of child language arises from the interplay of three factors: domain-specific principles of language (Universal Grammar), external experience, and properties of non-linguistic domains of cognition including general learning mechanisms and principles of efficient computation. We review developmental evidence that children make use of hierarchically composed structures ('Merge') from the earliest stages and at all levels of linguistic organization. At the same time, longitudinal trajectories of development show sensitivity to the quantity of specific patterns in the input, which suggests the use of probabilistic processes as well as inductive learning mechanisms that are suitable for the psychological constraints on language acquisition. By considering the place of language in human biology and evolution, we propose an approach that integrates principles from Universal Grammar and constraints from other domains of cognition. We outline some initial results of this approach as well as challenges for future research.
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http://dx.doi.org/10.1016/j.neubiorev.2016.12.023 | DOI Listing |
Nature
January 2025
Program of Mathematical Genomics, Department of Systems Biology, Columbia University, New York, NY, USA.
Transcriptional regulation, which involves a complex interplay between regulatory sequences and proteins, directs all biological processes. Computational models of transcription lack generalizability to accurately extrapolate to unseen cell types and conditions. Here we introduce GET (general expression transformer), an interpretable foundation model designed to uncover regulatory grammars across 213 human fetal and adult cell types.
View Article and Find Full Text PDFBioengineering (Basel)
December 2024
The Bhawanipur Education Society, Kolkata 700020, India.
Disease prediction using computer-based methods is now an established area of research. The importance of technological intervention is necessary for the better management of disease, as well as to optimize use of limited resources. Various AI-based methods for disease prediction have been documented in the literature.
View Article and Find Full Text PDFNat Commun
November 2024
Center for Sustainable Materials (SusMat), School of Materials Science and Engineering, Nanyang Technological University, 639798, Singapore, Singapore.
Phase-separating peptides (PSPs) self-assembling into coacervate microdroplets (CMs) are a promising class of intracellular delivery vehicles that can release macromolecular modalities deployed in a wide range of therapeutic treatments. However, the molecular grammar governing intracellular uptake and release kinetics of CMs remains elusive. Here, we systematically manipulate the sequence of PSPs to unravel the relationships between their molecular structure, the physical properties of the resulting CMs, and their delivery efficacy.
View Article and Find Full Text PDFThe subject of grammatical gender and cognition has been continuously examined in psycholinguistics, wherein findings show essential support for gender congruency effects, suggesting that grammar lends matrices for speakers' mental representations. Based on these psycholinguistic data, this study offers an innovative vista of investigation that combines typological and cognitive linguistic approaches. Its purpose lies in determining whether grammatical gender patterns sanction cross-linguistic universality in conceptualising entities as male or female, and whether grammatical gender universalities have semantic motivation.
View Article and Find Full Text PDFNat Lang Semant
April 2024
Department of Linguistics and English Language, The University of Manchester, Manchester, UK.
Persian possesses a number of stative complex predicates with 'to have' that express certain kinds of mental state. I propose that these be given a formal semantic treatment involving possession of a portion of an abstract quality by an individual, as in the analysis of property concept lexemes due to Francez and Koontz-Garboden (Language 91(3):533-563, 2015; Natural Language and Linguistic Theory 34:93-106, 2016; Semantics and morphosyntactic variation: Qualities and the grammar of property concepts, Oxford University Press, 2017). Augmented with an analysis of prepositional phrases introducing the target of the mental state and an approach to gradability in terms of measure functions (Wellwood in Measuring predicates, PhD dissertation, University of Maryland, College Park, 2014), the analysis explains various properties of possessive experiencer complex predicates, including the behavior of target phrases, the ability of the non-verbal element to be modified by a range of adjectives, the direct participation of the non-verbal element in comparative constructions, and the ability of degree expressions to modify both the non-verbal element and the VP containing the complex predicate.
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