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The presence of () infection has been indicated to have a protective influence on esophageal cancer (EC) in some studies, but its specific impact on the risk of esophageal squamous cell carcinoma and esophageal adenocarcinoma remains inconclusive. This manuscript comment addresses the recent study by López-Gómez . Despite it was a retrospective observational study without a control group, this study revealed a notably low prevalence of infection among EC patients, indicating a potential association between and EC in Spain.

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Role of in esophageal carcinogenesis: Friend or foe?

World J Gastroenterol

November 2024

Department of Gastroenterology, The First People's Hospital of Foshan, Foshan 528000, Guangdong Province, China.

In this letter, we comment on the article by López-Gómez , which explores the prevalence of () infection among patients with esophageal carcinoma (EC) in a cohort of Spain population. The relationship between infection and EC is very complex. Previous research results are often contradictory due to the influence of dietary habits, age, region, and other factors.

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Importance: Ongoing efforts have encouraged the regionalization of esophageal adenocarcinoma treatment to high-volume centers (HVCs). Yet such centralization has been linked with increased patient travel burden and reduced postoperative continuity of care.

Objective: To determine whether traveling to undergo esophagectomy at HVCs is linked with superior overall survival compared with receiving care locally at low-volume centers (LVC).

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