AI Article Synopsis
- The Ebola DNA vaccine is delivered through PLGA-PLL/γPGA nanoparticles using a microneedle patch, making it easier to administer on the skin.
- This nanoparticle system enhances the vaccine's stability and ability to provoke an immune response compared to traditional free vaccines.
- Using a microneedle patch for vaccination generates more robust immune responses than giving the vaccine through intramuscular injections.
Article Abstract
Ebola DNA vaccine is incorporated into PLGA-PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.
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| http://dx.doi.org/10.1002/adhm.201600750 | DOI Listing |
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