The distribution of two transuranic elements, plutonium and americium, in pregnant rats and in their fetuses, and the carcinogenic effects seen in progeny exposed perinatally are discussed. The appearance of malignant tumours in the liver and skeleton corresponds to the pattern of deposition of these radionuclides in the body.
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Biol Trace Elem Res
January 2025
Department of Environmental Management and Toxicology, Federal University of Agriculture, PMB 2240, Abeokuta, Ogun State, Nigeria.
Fish is a significant source of animal protein for humans; however, it has a tendency to bioaccumulate toxicants from the environment. The present study assessed the health risks associated with potential toxic metals (PTMs) in differently processed catfish (Clarias gariepinus) from four markets in Abeokuta metropolis, southwestern Nigeria. A total of 60 samples were collected and analyzed for PTMs using an Atomic Absorption Spectrophotometer.
View Article and Find Full Text PDFFront Cell Infect Microbiol
January 2025
United States National Poultry Research Center, United States Department of Agriculture Toxicology and Mycotoxin Research Unit, Athens, GA, United States.
The mycotoxigenic fungi, and , commonly co-colonize maize in the field, yet their direct interactions at the chemical communication level have not been well characterized. Here, we examined if and how the two most infamous mycotoxins produced by these species, aflatoxin and fumonisin, respectively, govern interspecies growth and mycotoxin production. We showed that fumonisin producing strains of suppressed the growth of while non-producers did not.
View Article and Find Full Text PDFTob Use Insights
January 2025
College of Medicine, Hebron University, Hebron, Palestine.
Background: Secondhand smoke (SHS) exposure remains a critical public health concern, especially for adolescents, who are more susceptible to its harmful effects and may initiate smoking as a result. SHS, comprising both mainstream and sidestream smoke, contains over 7000 chemicals, many of which are carcinogenic. Adolescents exposed to SHS are more likely to experiment with smoking due to environmental influences, peer pressure, and familial smoking behavior.
View Article and Find Full Text PDFJ Nanobiotechnology
January 2025
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Discipline of Intelligent Instrument and Equipment, Department of Experimental Medicine, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, China.
The numerous high-risk carcinogenic types of human papillomavirus (HR-HPV) that lack vaccine protection underscore the urgent need to develop broader-spectrum HPV vaccines. This study addresses this need by focusing on HR-HPV types 53, 56, and 66, which are not currently targeted by existing vaccines. It introduces an effective method for their soluble expression, as well as that of their mutants, within an Escherichia coli expression system.
View Article and Find Full Text PDFCytokine Growth Factor Rev
January 2025
Department of Hepatobiliary surgery, Chongqing University Affiliated Jiangjin Central Hospital, Chongqing, China. Electronic address:
Interleukin-6 (IL-6) is a pro-inflammatory cytokine playing a pivotal role during inflammation and immune responses. In the recent years, the function of IL-6 in the tumor microenvironment (TME) for affecting tumorigenesis and immunotherapy response has been investigated. The genetic mutations are mainly responsible for the development of cancer, while interactions in TME are also important, involving both cancers and non-cancerous cells.
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