AI Article Synopsis
- Neoadjuvant chemotherapy is now the standard treatment for locally advanced breast cancer, with anthracycline-based regimens like CAF being commonly used, though the addition of taxanes has shown better outcomes.* -
- This study aimed to compare the effectiveness and toxicity of a regimen combining paclitaxel and doxorubicin against the CAF regimen, using 101 patients with newly diagnosed breast cancer to evaluate treatment responses and monitor side effects.* -
- Results indicated that the paclitaxel/doxorubicin combination resulted in higher rates of complete response and pathological complete response compared to CAF, particularly benefiting patients with ER negative tumors, supporting its recommendation as a first-line treatment.*
Article Abstract
Background: Neoadjuvant chemotherapy has become the standard recommendation in the management of patients with locally advanced breast cancer. At present anthracycline based regimen such as CAF (cyclophosphamide, adriamycin and 5-FU) is widely used in clinical practice. The introduction of taxanes has revolutionized this field because of superior results.
Aims And Objectives: This study is designed to compare the efficacy of paclitaxel plus doxorubicin regimen and CAF (cyclophosphamide, doxorubicin and 5-fluorouracil) regimen as neoadjuvant treatment of locally advanced breast cancer and to compare their toxicity profiles and also to correlate the hormonal receptor status in predicting response to the NACT.
Materials And Methods: In this prospective study, 101 patients with newly diagnosed locally advanced breast cancer were randomized to receive either CAF or Paclitaxel/adriamycin as NACT for three cycles. The response was assessed objectively using CT scans and applying RECIST criteria. The patients were monitored for hematologic, cardiac and other minor toxicities.
Results: There was a significantly increased complete and objective response seen in the AP group when compared to CAF group (24% and 58% in the AP group versus 7.8% and 39.2% in the CAF group, P value 0.0313 for complete response). The pCR rate was also significantly higher in the AP group compared to CAF group. (20.93% versus 4.34%, P value 0.0237). There was no significant difference between the groups with respect to cardiotoxicity and hematotoxicity. Patients with ER negative tumors have responded well to neoadjuvant chemotherapy better than ER positive patients. (Objective response 62.8% vs. 40%, P - 0.0473).
Conclusions: Based on these results, taxane based regimen such as Paclitaxel/adriamycin can be recommended as a first line neoadjuvant regimen in patients with locally advanced breast cancer.
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| http://dx.doi.org/10.4103/0019-509X.197715 | DOI Listing |
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