Background: Current drugs available for the treatment of Chagas disease are fraught with several challenges including severe toxicity and limited efficacy. These factors coupled with the absence of effective drugs for treating the chronic stage of the disease have rendered the development of new drugs against Chagas disease a priority.
Objective: This study screened several imidazole-based compounds for anti-Trypanosoma potential.
Method: Using an in vitro experimental infection model, several imidazole-based compounds were screened for anti-proliferative effect on Trypanosoma cruzi epimastigotes. Additionally, all test compounds were evaluated for unspecific cytotoxicity on L929 murine fibroblasts. Benznidazole (BZN) served as reference drug.
Results: All test compounds demonstrated interesting trypanocidal potential with IC50 values in the μM range (1< 1C50 <8 μM). The activities of the test compounds compared favorably with BZN, which had an IC50 value ca. 30 μM. Conversely, most of the test compounds were highly cytotoxic, resulting in selectivity lower than that of BZN (SI > 9.42).
Conclusion: We provide evidence which implicate the imidazole-based compounds as potential prototypes for the development of anti-parasitic agents. Findings have far-reaching relevance to drug discovery efforts for trypanosomiasis.
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Article Synopsis
- Toxoplasmosis, caused by the parasite Toxoplasma gondii, affects about one-third of humans, and there's a need for new treatments due to the lack of effective options.
- Researchers used computational methods to screen 3000 compounds, ultimately identifying nine candidate compounds that were tested against T. gondii in the lab.
- Among these, C5 showed promising anti-parasitic effects by inhibiting parasite growth and replication, while also increasing reactive oxygen species levels, although it exhibited some toxicity towards host cells as well.
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