Assignment of polymorphic species of insulin analogues in ion mobility mass spectroscopy.

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Federal University of Rio de Janeiro - UFRJ, Av. Carlos Chagas Filho 373, CCS, Bss24, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, Brazil; Laboratory for Macromolecules (LAMAC-DIMAV), Brazilian National Institute of Metrology, Quality and Technology - INMETRO, Av. N. Sa. das Graças, 50 - Xerém, Duque de Caxias 25250-020, Rio de Janeiro, Brazil; National Institute of Science and Technology for Structural Biology and Bioimaging (INBEB-INCT), Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.

Published: February 2017

Electrospray ionization - ion mobility spectrometry - mass spectrometry (ESI-IMS-MS) allows the identification of protein polymorphic distribution of protein conformers and oligomers. We report the detailed identification of the species observed with commercially available pharmaceutical preparation of wild-type, regular human insulin.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219646PMC
http://dx.doi.org/10.1016/j.dib.2016.12.020DOI Listing

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