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LPS infusion suppresses serum FGF21 levels in healthy adult volunteers. | LitMetric

LPS infusion suppresses serum FGF21 levels in healthy adult volunteers.

Endocr Connect

The Medical Research LaboratoriesInstitute of Clinical Research, Aarhus University, Aarhus C, Denmark.

Published: January 2017

Context: During the inflammatory acute phase response, plasma glucose and serum triglycerides are increased in humans. Fibroblast growth factor (FGF) 21 has plasma glucose and lipid-reducing actions, but its role in the acute inflammatory response in human is unknown.

Objective: To investigate circulating levels of FGF21 after lipopolysaccharide (LPS) infusion.

Design: Two randomized, single-blinded, placebo-controlled crossover trials were used.

Setting: The studies were performed at a university hospital clinical research center.

Patients And Interventions: Study 1 (LPS bolus): Eight young, healthy, lean males were investigated two times: (1) after isotonic saline injection and (2) after LPS injection (bolus of 1 ng/kg). Each study day lasted 4 h. Study 2 (continuous LPS infusion): Eight, healthy males were investigated two times: (1) during continuously isotonic saline infusion and (2) during continuous LPS infusion (0.06 ng/kg/h). Each study day lasted 4 h. Circulating FGF21 levels were quantified every second hour by an immunoassay.

Results: A LPS bolus resulted in a late suppression (t = 240 min) of serum FGF21 (P = 0.035). Continuous LPS infusion revealed no significant effects on FGF21 levels (P = 0.82).

Conclusions: Our studies show that a bolus of LPS results in decreased FGF21 levels 4 h from exposure.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302167PMC
http://dx.doi.org/10.1530/EC-16-0103DOI Listing

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