Population of atoxigenic Eltor vibrios (vct-) isolated from open water has been shown to be heterogeneous by the genomic fingerprinting technique. Epidemically dangerous strains (vct+) containing the gene coding for cholera toxin have similar hybridization profile independent of time and place of their isolation. The clonal formation of vct+ strains and the absence of vct----vct+ transition of strains under natural conditions are discussed.
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