Enzyme-responsive reporter molecules for selective localization and fluorescence imaging of pathogenic biofilms.

Chem Commun (Camb)

Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore. and Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, 117602, Singapore.

Published: March 2017

Pathogenic bacteria and their biofilm formation are responsible for a broad spectrum of microbial infections. A novel enzyme-responsive reporter molecule (ERM-1), which can specifically recognize AmpC β-lactamase (Bla) in drug resistant bacteria, has been developed to enable the selective localization of biofilms.

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http://dx.doi.org/10.1039/c6cc09296aDOI Listing

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