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Apoptosis induced by Fas signaling does not alter hepatic hepcidin expression.
World J Biol Chem
August 2014
Sizhao Lu, Emily Zmijewski, John Gollan, Duygu Dee Harrison-Findik, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5820, United States.
Aim: To determine the regulation of human hepcidin (HAMP) and mouse hepcidin (hepcidin-1 and hepcidin-2) gene expression in the liver by apoptosis using in vivo and in vitro experimental models.
Methods: For the induction of the extrinsic apoptotic pathway, HepG2 cells were treated with various concentrations of CH11, an activating antibody for human Fas receptor, for 12 h. Male C57BL/6NCR and C57BL/6J strains of mice were injected intraperitoneally with sublethal doses of an activating antibody for mouse Fas receptor, Jo2.
Assessing the distribution and protection status of two types of cool environment to facilitate their conservation under climate change.
Conserv Biol
April 2014
University of Technology, Sydney, School of the Environment, P.O. Box 123, Broadway, New South Wales, 2007, Australia; Australian Museum, 6 College Street, Sydney, New South Wales, Australia.
Strategies to mitigate climate change can protect different types of cool environments. Two are receiving much attention: protection of ephemeral refuges (i.e.
View Article and Find Full Text PDFCan volunteers collect data that are comparable to professional scientists? A study of variables used in monitoring the outcomes of ecosystem rehabilitation.
Environ Manage
November 2012
Australian Musuem, 6 College St, Sydney, NSW 2010, Australia.
Having volunteers collect data can be a cost-effective strategy to complement or replace those collected by scientists. The quality of these data is essential where field-collected data are used to monitor progress against predetermined standards because they provide decision makers with confidence that choices they make will not cause more harm than good. The integrity of volunteer-collected data is often doubted.
View Article and Find Full Text PDFRegulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling.
Am J Physiol Gastrointest Liver Physiol
January 2009
Division of Gastroenterology/Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 95820 UNMC, Omaha, NE 68198-5820, USA.
Alcohol downregulates hepcidin expression in the liver leading to an increase in intestinal iron transport and liver iron storage. We have previously demonstrated that alcohol-mediated oxidative stress is involved in the inhibition of hepcidin transcription by alcohol in vivo. Kupffer cells and TNF-alpha play a key role in alcohol-induced liver injury.
View Article and Find Full Text PDFIron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol.
Hepatology
December 2007
Division of Gastroenterology/Hepatology, Department of Internal Medicine, Houston, TX, USA.
Unlabelled: Alcohol reduces and iron increases liver hepcidin synthesis. This study investigates the interaction of alcohol and iron in the regulation of hepcidin messenger RNA (mRNA) expression in animal models. Mice were administered 10% ethanol for 7 days after an iron-overloaded diet.
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