AI Article Synopsis
- The study compared the antitumor effects of pristine C fullerene aqueous solution (CFAS) with conventional cytostatic drugs like 5-fluorouracil (5-FU) and a pyrrole derivative (MI-1) in a rat model of colorectal cancer.
- The results showed a significant reduction in the number and size of tumors when treated with CFAS and MI-1, indicating their effectiveness in combating cancer.
- The research suggests that using CFAS and MI-1 together could enhance treatment outcomes and minimize side effects due to their distinct mechanisms of action.
Article Abstract
The antitumor activity of pristine C fullerene aqueous solution (CFAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF-fenylamino)-1H-pyrrol-2.5-dione (MI-1) cytostatic drugs was investigated and analyzed in detail using the model of colorectal cancer induced by 1.2-dimethylhydrazine (DMH) in rats. The number, size, and location of the tumors were measured, and the pathology was examined. It was found that the number of tumors and total lesion area decreased significantly under the action of CFAS and MI-1. Because these drugs have different mechanisms of action, their simultaneous administration can potentially increase the effectiveness and significantly reduce the side effects of antitumor therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215998 | PMC |
| http://dx.doi.org/10.1186/s11671-016-1775-0 | DOI Listing |
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