Both monomeric and dimeric tetraacetylglucose-containing {Fe(NO)} dinitrosyl iron complexes (DNICs) were prepared and examined for NO release in the presence of both chemical NO-trapping agents and endothelial cells.
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http://dx.doi.org/10.1039/c6cc08659d | DOI Listing |
Inorg Chem
January 2025
Department of Chemistry, UiT The Arctic University of Norway, N-9037 Tromso̷, Norway.
Building upon an earlier study of heme-nitrosyl complexes (. , , 20496-20505), we examined a wide range of nonheme {FeNO} complexes (the superscript represents the Enemark-Feltham count) and two dinitrosyl iron complexes using DMRG-CASSCF calculations. Analysis of the wave functions in terms of resonance forms with different [π*(NO)] occupancies (where = 0-4 for mononitrosyl complexes) identified the dominant electronic configurations of {FeNO} and {FeNO} complexes as Fe-NO and Fe-NO, respectively, mirroring our previous findings on heme-nitrosyl complexes.
View Article and Find Full Text PDFInorg Chem
December 2024
School of Chemical Sciences, Indian Association for the Cultivation of Science, 2A & 2B Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India.
Reaction of an Fe(II) complex, [Fe(6-COO-tpa)] (), with PhE and NO produced [Fe(6-COO-tpa)(EPh)] (E = S, ; Se, ) and [Fe(6-COO-tpa)κO,O'-NO)] (), respectively (6-COOH-tpa is bis(2-pyridylmethyl)(6-carboxyl-2-pyridylmethyl)amine). Treatment of with 2 equiv of PhEH (E = S, Se) produced NO in ∼40% yields, respectively, along with and the DNICs, [Fe(EPh)(NO)] (E = S, Se). Treatment of with excess PhEH produced NO in similar yields, while was converted to the same DNICs and / (instead of ).
View Article and Find Full Text PDFBull Exp Biol Med
October 2024
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
The concentrations of nitric oxide (NO) donors in the plasma of pregnant women with preeclampsia is several times higher than in healthy pregnant women. Antihypertensive drugs acting not through the NO-mediated mechanisms normalized BP in some women with preeclampsia, but did not significantly reduce the levels of NO donors in the plasma. It appears that preeclampsia is associated with insufficient NO availability for the targets, rather than low intensity of NO synthesis.
View Article and Find Full Text PDFJ Inorg Biochem
January 2025
Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Moscow region, prosp. Akad. Semenova, 1, 142432 Chernogolovka, Russian Federation; Faculty of Fundamental Physical and Chemical Engineering, Lomonosov Moscow State University M.V. Lomonosov, Leninskie gory, 1, 119991 Moscow, Russian Federation; Scientific and Educational Center "Medical Chemistry" in Chernogolovka, Federal State Autonomous Educational Institution of Higher Education "State University of Education", Moscow Region, st. Vera Voloshina, 24, 141014 Mytishchi, Russian Federation.
A new promising binuclear tetranitrosyl iron complex with 2-methoxythiophenolyl of the composition [Fe(CHOS)(NO)] (complex 1), which acts on the therapeutic targets of cardiovascular diseases, guanylate and adenylate cyclase, has been synthesized. X-ray diffraction data show the presence of two isoforms of complex 1; according to quantum chemical calculations, the structure of only the trans isomer is stable in solutions. The processes of transformation of complex 1 in DMSO, in aqueous solutions, as well as in the presence of bovine serum albumin, reduced glutathione, and mucin were studied.
View Article and Find Full Text PDFBull Exp Biol Med
June 2024
Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.
The effect of a promising NO donor, a binuclear nitrosyl iron complex (NIC) with 3,4-dichlorothiophenolyls [Fe(SCHCl)(NO)], on the adenylate cyclase and soluble guanylate cyclase enzymatic systems was studied. In in vitro experiments, this complex increased the concentration of important secondary messengers, such as cAMP and cGMP. An increase of their level by 2.
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