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Effects of Volatile Anesthetics on Postoperative Ischemic Stroke Incidence.
J Am Heart Assoc
February 2021
Department of Anesthesia, Critical Care and Pain Medicine Beth Israel Deaconess Medical CenterHarvard Medical School Boston MA.
Background Preclinical studies suggest that volatile anesthetics decrease infarct volume and improve the outcome of ischemic stroke. This study aims to determine their effect during noncardiac surgery on postoperative ischemic stroke incidence. Methods and Results This was a retrospective cohort study of surgical patients undergoing general anesthesia at 2 tertiary care centers in Boston, MA, between October 2005 and September 2017.
View Article and Find Full Text PDFEnd-tidal to Arterial Gradients and Alveolar Deadspace for Anesthetic Agents.
Anesthesiology
September 2020
From the Anaesthesia, Perioperative and Pain Medicine Program, Centre for Integrated Critical Care, University of Melbourne, Melbourne, Australia (P.J.P.) the Department of Anaesthesia, Austin Health, Victoria, Australia (P.J.P.) the Institute for Breathing and Sleep, Victoria, Australia (P.J.P.) the Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium (J.H.) the Department of Anesthesiology, Onze-Lieve-Vrouw (OLV) Hospital, Aalst, Belgium (J.H.) the Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands (R.J.E.G.) the Discipline of Anaesthesiology, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, Australia (A.V.Z.) the Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (A.D.W.).
Background: According to the "three-compartment" model of ventilation-perfusion ((Equation is included in full-text article.)) inequality, increased (Equation is included in full-text article.)scatter in the lung under general anesthesia is reflected in increased alveolar deadspace fraction (VDA/VA) customarily measured using end-tidal to arterial (A-a) partial pressure gradients for carbon dioxide.
View Article and Find Full Text PDFGenomics and Proteomic Techniques.
Methods Enzymol
March 2019
University of California at San Francisco, San Francisco, CA, United States. Electronic address:
Although general anesthesia induced by inhaled anesthetics produces definitive phenotypes (e.g., loss of mobility, amnesia, analgesia), the underlying targets of these drugs are still not clear.
View Article and Find Full Text PDFGenetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster.
Sci Rep
February 2018
Department of Anesthesiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Genetic variability affects the response to numerous xenobiotics but its role in the clinically-observed irregular responses to general anesthetics remains uncertain. To investigate the pharmacogenetics of volatile general anesthetics (VGAs), we developed a Serial Anesthesia Array apparatus to expose multiple Drosophila melanogaster samples to VGAs and behavioral assays to determine pharmacokinetic and pharmacodynamic properties of VGAs. We studied the VGAs isoflurane and sevoflurane in four wild type strains from the Drosophila Genetic Reference Panel, two commonly used laboratory strains (Canton S and w ), and a mutant in Complex I of the mitochondrial electron transport chain (ND23 ).
View Article and Find Full Text PDFSevoflurane and Isoflurane-Pharmacokinetics, Hemodynamic Stability and Cardio-protective Effects During Cardiopulmonary Bypass.
J Cardiothorac Vasc Anesth
December 2017
Department of Anesthesiology and Intensive Care Medicine, University Hospital Basel, Basel, Switzerland.
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