Objective: Oral appliances (OA) are recommended for patients with severe obstructive sleep apnea who fail to comply with continuous positive airway pressure (CPAP) therapy. This mixed-methods study aimed to quantify adherence to OA therapy and evaluate subjective reasons associated with non-adherence.
Materials And Methods: The medical records of 52 patients with an apnea-hypopnea index (AHI) ≥ 40, treated with OA after discontinuation of CPAP treatment, were examined for OA adherence. Patients were divided according to usage at the time of a phone interview. The USER group included all forms of usage, whereas those who completely ceased using the OA were in the NUSE group. The timing of the phone interview was from five months to six years (average 44.63 ± 17.17 months) after OA delivery.
Results: The overall adherence rate was 57.7% (30/52 patients). The mean usage times were 10.07 ± 8.96 and 44.30 ± 17.3 months in the NUSE and NUSE groups, respectively. The main factors associated with non-adherence were concerns about the effects of the OA on teeth (22%) and insufficient efficacy (22%). Other factors were discomfort (15%) and improved well-being following weight loss (15%). The overall number of interfering and discontinuity factors was significantly higher in the NUSE group than in the USER group (P = 0.041). Nine (17.3%) of 52 patients resumed CPAP use. Subjective and objective outcomes, determined by using a second sleep test with OA in 69.2% of patients, were related to the continuation of treatment.
Conclusions: On-adherence to OA is strongly associated with patient reservations regarding the effects of the device on teeth, possible lack of efficacy, and discomfort. Clinicians should closely monitor adherence patterns and assess potential interfering factors during their diagnostic workup. Patients should be reassured regarding device safety, particularly following dental work that may interfere with the insertion of the OA.
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http://dx.doi.org/10.1111/odi.12633 | DOI Listing |
PLoS One
January 2025
Zhanhua District Power Supply Company, Binzhou, China.
Interfered by external factors, the receptive field limits the traditional CNN multispectral remote sensing building change detection method. It is difficult to obtain detailed building changes entirely, and redundant information is reused in the encoding stage, which reduces the feature representation and detection performance. To address these limitations, we design a Siamese network of shared attention aggregation to learn the detailed semantics of buildings in multispectral remote sensing images.
View Article and Find Full Text PDFFront Public Health
January 2025
West China Hospital/West China School of Nursing, Sichuan University, Chengdu, China.
Aims: The study aims to explore the relationship between impostor phenomenon and emotional exhaustion among nurses and to examine the potential mediating role of bi-directional work-family conflict.
Methods: A cross-sectional survey using convenience sampling was conducted from January to April 2023, involving 4,088 Chinese nurses. Of those, 3,977 nurses across 43 public hospitals completed the web-based survey that included a sociodemographic information questionnaire, the short Clance Impostor Phenomenon Scale, the Bi-directional Scale of Work-Family Conflict, and the Emotional Exhaustion Scale.
Int J Biol Macromol
January 2025
College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China. Electronic address:
Urban air pollutants, mainly represented by PM containing organic and inorganic substances, can penetrate the human skin and trigger oxidative stress, potentially causing skin barrier damage and aging. κ-Carrageenan oligosaccharides as degradation products of natural sulfated polysaccharide have a great potential for skin moisturization as well as improving oxidative stress and inflammation. In this study, κ-carrageenan tetrasaccharide was obtained by enzymatic digestion of κ-carrageenan, and its role in alleviating particulate matter-induced inflammatory response in HaCaT keratinocyte cell line and skin barrier dysfunction was evaluated.
View Article and Find Full Text PDFInt Immunopharmacol
January 2025
The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou 646000 Sichuan, China. Electronic address:
Background: Peri-implantitis is an inflammatory bone disease that seriously affects the health of dental implants. Pyroptosis plays an important role in peri-implantitis and inhibition of pyroptosis may point out a new direction for treating the disease. The long non-coding RNA Negative Regulator of Interferon Response (lncRNA NRIR) is closely related to peri-implantitis and may be involved in the process of pyroptosis.
View Article and Find Full Text PDFCell Biol Int
January 2025
Microscopy and Microanalysis Center, Institute of Biosciences, Letters and Exact Sciences (IBILCE), São Paulo State University (Unesp), São José do Rio Preto, SP, Brazil.
Mammary glands development is influenced by endocrine signaling, which remodels epithelial and stromal compartments. Reactive stroma phenotype is observed when stromal disturbances occur, leading to changes in extracellular matrix composition and occurrence of reactive cell types. One of the triggers of these alterations is endocrine-disrupting chemical exposure, such as bisphenol A (BPA).
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