Synthesis of chiral (tetrazolyl)methyl-containing acrylates via silicon-induced organocatalytic kinetic resolution of Morita-Baylis-Hillman fluorides.

Takayuki Nishimine Hiromi Taira Satoru Mori Okiya Matsubara Etsuko Tokunaga Hidehiko Akiyama Vadim A Soloshonok Norio Shibata

Chem Commun (Camb)

Department of Nanopharmaceutical Sciences & Department of Frontier Materials, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.

Published: January 2017

Reported herein is a new approach for the asymmetric installation of a (tetrazolyl)methyl group via Si/F activation using organocatalytic kinetic resolution of racemic MBH-fluorides.

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http://dx.doi.org/10.1039/c6cc08830a	DOI Listing

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