AI Article Synopsis
- PEComas are rare soft tissue tumors with varying histological appearances that exhibit different levels of the pericyte antigen markers.
- The study expanded on previous research by investigating the expression of Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) in human tumor samples through immunohistochemical methods.
- Ang-1 was not found in any PEComa tumors, while Ang-2 expression varied based on the tumor's cytologic characteristics, suggesting a potential link to the pericytic origin or abnormal adoption of these markers.
Article Abstract
Objective: Perivascular epithelioid cell tumors (PEComa) are an uncommon family of soft tissue tumors. Previously, we described that the presence of pericyte antigens among PEComa family tumors differs extensively by histologic appearance.
Methods: Here, we extend our findings using the pericyte antigens Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2), using immunohistochemical detection in human tumor samples.
Results: While Ang-1 showed no expression across any PEComa family tumor, Ang-2 showed expression that like other pericyte markers was largely determined by cytologic appearance.
Conclusion/implications: Pericytic marker expression in PEComa may represent a true pericytic cell of origin, or alternatively aberrant pericyte marker adoption.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196089 | PMC |
| http://dx.doi.org/10.1016/j.jor.2016.12.001 | DOI Listing |
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