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| http://dx.doi.org/10.1093/pm/pnw296 | DOI Listing |
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Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury.
Hepatol Commun
February 2025
Department of Surgery, University of California, San Francisco, San Francisco, California, USA.
Background: Rho-associated kinases 1 and 2 (ROCK1 and ROCK2) regulate critical cell functions, including actomyosin contractility, apoptosis, and proliferation. Some studies suggest that ROCK inhibition may serve as a treatment for liver fibrosis. More investigation is needed to understand the role of hepatocyte ROCK signaling in vivo, especially in the context of profibrotic liver injury.
View Article and Find Full Text PDFInsulin, IGF-I, and lactoferrin concentrations and yields and their associations with other components within colostrum, transition, and whole milk of primiparous and multiparous Holstein cattle.
JDS Commun
January 2025
Department of Animal Biosciences, Animal Science and Nutrition, University of Guelph, Guelph, ON, Canada N1G 1Y2.
The primary objective of the study was to characterize concentrations and yields of lactoferrin (LF), insulin, and IGF-I in colostrum, transition milk (TM), and whole milk (WM) of multiparous (MP) and primiparous (PP) cows. A secondary objective was to determine associations between colostrum and TM components (fat, protein, lactose), IgG, and bioactive compounds (oligosaccharides, LF, insulin, IGF-I; defined as compounds present in micro quantities that stimulate physiological responses systemically or locally within the neonate). Holstein cows (10 MP and 10 PP) were assigned to the study at calving and colostrum was collected 5.
View Article and Find Full Text PDFhigh-content screening reveals miR-429 as a protective molecule in photoreceptor degeneration.
Mol Ther Nucleic Acids
March 2025
Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
Inherited retinal diseases (IRDs) are clinically and genetically heterogeneous disorders characterized by progressive photoreceptor degeneration and irreversible vision loss. MicroRNAs (miRNAs), a class of endogenous non-coding RNAs with post-transcriptional regulatory properties, are known to play a major role in retinal function, both in physiological and pathological conditions. Given their ability to simultaneously modulate multiple molecular pathways, miRNAs represent promising therapeutic tools for disorders with high genetic heterogeneity, such as IRDs.
View Article and Find Full Text PDFRhodamine-functionalized carbon dots with pH-regulated FRET efficiency for ratiometric fluorescence sensing and imaging of extremely alkaline pH.
Mikrochim Acta
January 2025
School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China.
A ratiometric fluorescent nanoprobe (CDs-Rho), synthesized through the simple covalent amide linkage between carbon dots (CDs) and pH-sensitive rhodamine dye (Rho), was designed for the precise sensing and imaging of extremely alkaline environments. The sensing mechanism involves the opposite pH-dependent fluorescence changes in CDs and Rho, respectively, coupled with pH-regulated FRET efficiency from CDs to Rho. The nanoprobe features a wide pH response window from pH 7.
View Article and Find Full Text PDFUtilizing simulation-enhanced interprofessional education to identify differences in healthcare students' collaborative practice behaviors: A mixed method study.
Nurse Educ Today
January 2025
Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, University of Illinois Chicago, United States of America; 801 S. Paulina St. Room 204B, Chicago, IL 60612, United States of America. Electronic address:
Background: Teaching collaborative practice behaviors (CPBs) to interprofessional healthcare students could improve healthcare for underserved populations.
Objective: This study explained the impact of Simulation Enhanced Interprofessional Education (SIM-IPE) on healthcare students' self-reported CPBs and their perceptions of utilizing CPBs when caring for underserved populations, as well as the differences among professions within interprofessional teams.
Design: Mixed methods explanatory design.
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