Plasmids of Distinct IncK Lineages Show Compatible Phenotypes.

Antimicrob Agents Chemother

Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

Published: March 2017

IncK plasmids are some of the main carriers of and genes and show high similarity to other plasmids belonging to the I complex, including IncB/O plasmids. Here, we studied the phylogenetic relationship of 37 newly sequenced IncK and IncB/O plasmids. We show that IncK plasmids can be divided into two compatible lineages named IncK1 and IncK2.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328535PMC
http://dx.doi.org/10.1128/AAC.01954-16DOI Listing

Publication Analysis

Top Keywords

inck plasmids
8
incb/o plasmids
8
plasmids
6
plasmids distinct
4
inck
4
distinct inck
4
inck lineages
4
lineages compatible
4
compatible phenotypes
4
phenotypes inck
4

Similar Publications

Natural products from food sources can alter the spread of antimicrobial resistance plasmids in .

Microbiology (Reading)

August 2024

Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Article Synopsis
  • - Antimicrobial resistance (AMR), especially against important antibiotics like carbapenems, is a major global health issue caused by the transfer of resistance genes on plasmids between bacteria.
  • - Researchers investigated natural product extracts for their ability to lower the transfer of AMR plasmids between bacterial strains, finding that many extracts, especially rottlerin, showed promise in reducing this transfer.
  • - While the natural products decreased conjugation rates slightly, the effects were not substantial enough to significantly impact AMR on a larger scale, suggesting that compounds like rottlerin warrant further research for improving anti-plasmid activity.
View Article and Find Full Text PDF

carrying IncK- plasmids mediating resistance to extended-spectrum cephalosporins (ESC) has been frequently described in food-producing animals and in humans. This study aimed to characterize IncK--positive ESC-resistant isolates from poultry production systems in Denmark, Finland, and Germany, as well as from Danish human blood infections, and further compare their plasmids. Whole-genome sequencing (Illumina) of all isolates ( = 46) confirmed the presence of the gene.

View Article and Find Full Text PDF

Understanding the genetic basis of the incompatibility of IncK1 and IncK2 plasmids.

Open Res Eur

October 2023

Wageningen Bioveterinary Research, Lelystd, 8221 RA, The Netherlands.

Article Synopsis
  • * This study investigates the interaction between two subgroups of I-complex plasmids, IncK1 and IncK2, focusing on their RNAI structures, which differ by only five nucleotides and determine their compatibility.
  • * Through experiments with minireplicons and targeted mutations, the research found that only specific nucleotide changes in the RNAI structure affect compatibility, highlighting the importance of these findings for predicting plasmid behavior in future research.
View Article and Find Full Text PDF

The emergence of extended-spectrum cephalosporin (ESC)-resistant is a global concern. This study aimed to assess the prevalence and transmission of ESC-resistant in the Danish broiler production system. Samples from two vertically integrated Production Systems (1 and 2) and two slaughterhouses (A and B) were analyzed (n = 943) for the occurrence of ESC-resistant from 2015 to 2018.

View Article and Find Full Text PDF

Polyclonal Spread of Fosfomycin Resistance among Carbapenemase-Producing Members of the in the Czech Republic.

Microbiol Spectr

June 2023

Department of Microbiology, Faculty of Medicine, University Hospital in Pilsen, Charles University, Pilsen, Czech Republic.

Fosfomycin (FOS) has been recently reintroduced into clinical practice, but its effectiveness against multidrug-resistant (MDR) is reduced due to the emergence of FOS resistance. The copresence of carbapenemases and FOS resistance could drastically limit antibiotic treatment. The aims of this study were (i) to investigate fosfomycin susceptibility profiles among carbapenem-resistant (CRE) in the Czech Republic, (ii) to characterize the genetic environment of genes among the collection, and (iii) to evaluate the presence of amino acid mutations in proteins involved in FOS resistance mechanisms.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!