AI Article Synopsis
- Endogenous retroviruses (ERVs), making up 8% of the human genome, are linked to the regulation of gene networks in the developing brain.
- In this study, researchers discovered a distinct expression pattern of ERVs that varies by region and developmental stage in human brain development.
- They found that nearly 10,000 primate-specific ERVs interact with the protein TRIM28 in neural progenitor cells, leading to gene repression and influencing the expression of nearby genes crucial for brain development.
Article Abstract
Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of gene expression of protein-coding transcripts important for brain development.
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| http://dx.doi.org/10.1016/j.celrep.2016.12.010 | DOI Listing |
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