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At the nucleus of cancer: how the nuclear envelope controls tumor progression.
MedComm (2020)
February 2025
Historically considered downstream effects of tumorigenesis-arising from changes in DNA content or chromatin organization-nuclear alterations have long been seen as mere prognostic markers within a genome-centric model of cancer. However, recent findings have placed the nuclear envelope (NE) at the forefront of tumor progression, highlighting its active role in mediating cellular responses to mechanical forces. Despite significant progress, the precise interplay between NE components and cancer progression remains under debate.
View Article and Find Full Text PDFLipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress.
ACS Cent Sci
January 2025
The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Harwell OX11 0FA, U.K.
Protein N-glycosylation is a cotranslational modification that takes place in the endoplasmic reticulum (ER). Disruption of this process can result in accumulation of misfolded proteins, known as ER stress. In response, the unfolded protein response (UPR) restores proteostasis or responds by controlling cellular fate, including increased expression of activating transcription factor 4 (ATF4) that can lead to apoptosis.
View Article and Find Full Text PDFA Precise Oxide Film Thickness Measurement Method Based on Swept Frequency and Transmission Cable Impedance Correction.
Sensors (Basel)
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School of Information Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Accurately measuring the thickness of the oxide film that accumulates on nuclear fuel assemblies is critical for maintaining nuclear power plant safety. Oxide film thickness typically ranges from a few micrometers to several tens of micrometers, necessitating a high-precision measurement system. Eddy current testing (ECT) is commonly employed during poolside inspections due to its simplicity and ease of on-site implementation.
View Article and Find Full Text PDFUHPC Viability for Nuclear Storage Facilities: Synthesis and Critical Review of Durability, Thermal, and Nuclear Properties for Informed Mix Modifications.
Materials (Basel)
January 2025
Department of Civil and Environmental Engineering, University of Nevada, Reno, NV 89557, USA.
Spent nuclear fuel (SNF) from the United States' nuclear power plants has been placed in dry cask storage systems since the 1980s. Due to the lack of a clear path for permanent geological repository for SNF, consolidated and long-term storage solutions that use durable concrete and avoid current aging and licensing challenges are becoming indispensable. Ultra-high-performance concrete (UHPC) is a rapidly growing advanced concrete solution with superior mechanical and durability properties that can help realize future resilient nuclear storage facilities.
View Article and Find Full Text PDFRelay Protection Device Reliability Assessment Through Radiation, Fault Injection and Fault Tree Analysis.
Micromachines (Basel)
January 2025
School of Nuclear Science and Technology, Xi'an Jiaotong University, Xi'an 710071, China.
Relay protection devices must operate continuously throughout the year without anomalies. With the integration of advanced technology and process chips in secondary equipment, new risks need to be addressed to ensure the reliability of these relay protection devices. One such risk is the impact of α-particles inducing single event effects (SEEs) on the secondary equipment.
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