AI Article Synopsis
- Purpose: The study investigates the long-term effects of combining repetitive transcranial magnetic stimulation (rTMS) with cognitive training on brain activity in Alzheimer’s disease (AD) patients, since existing medications have limited impact on slowing cognitive decline.
- Methods: Researchers measured brain electrical activity (EEG) in seven mild AD patients before treatment and after each session during 54 treatment sessions over 4.5 months to assess the effects of rTMS and cognitive training.
- Results: After treatment, there was a significant increase in brain activity (delta) in the temporal region, along with various nonsignificant changes in other brain wave patterns, suggesting potential benefits; higher alpha activity correlated positively with cognitive performance over time,
Article Abstract
Purpose: Medications are the currently accepted symptomatic treatment of Alzheimer disease (AD), but their impact on delaying the progression of cognitive deficits and functional impairment is limited. The authors aimed to explore long-term electrophysiological effects of repetitive transcranial magnetic stimulation interlaced with cognitive training on quantitative electroencephalography (EEG) in patients with AD.
Methods: Quantitative EEG was assessed on non-repetitive transcranial magnetic stimulation interlaced with cognitive training treatment days before treatment and after each treatment phase in seven patients with mild AD.
Results: After 4.5 months (54 sessions) of treatment, a significant increase of delta activity over the temporal region was found compared with pretreatment values. Nonsignificant increases of the log EEG power were found for alpha band over the frontal and temporal regions, beta band over the frontal region, theta band over the frontal, temporal, and parieto-occipital regions, and delta band over the frontal and parieto-occipital regions. Nonsignificant decreases were found for alpha over the parieto-occipital region, and for beta over the temporal and parieto-occipital regions. A positive correlation was found between log alpha power over the frontal and temporal regions at 6 weeks and Mini-Mental State Examination (MMSE) scores at 6 weeks and 4.5 months, and between log alpha power over the parieto-occipital regions and MMSE scores at 6 weeks. A negative correlation was found between log alpha power over the frontal and temporal regions at 6 weeks and baseline Alzheimer's Disease Assessment Scale-cognitive subscale scores.
Conclusions: Repetitive transcranial magnetic stimulation interlaced with cognitive training has long-term effects on quantitative EEG in patients with mild AD. Further research on the quantitative EEG long-term effects of transcranial magnetic stimulation interlaced with cognitive training is required to confirm the authors' data.
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| http://dx.doi.org/10.1097/WNP.0000000000000301 | DOI Listing |
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