The toxicity of simple imidazolium and benzimidazolium salts started to be more and more investigated in the last few years and was taken in consideration in the context of microorganisms, plants and more evolved organisms' exposure. However, the toxicity of these salts can be exploited in the development of different biological applications by incorporating them in the structure of compounds that specifically target microorganisms and cancer cells. We highlight in this minireview the way researchers became aware of the inherent problem of the stability and bioaccumulation of imidazolium and benzimidazolium salts and how they found inspiration to exploit their toxicity by incorporating them into new highly potent drugs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c6ob02293f | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fluorinated -Heterocyclic Carbene Silver(I) Complexes with High Cancer Cell Selectivity.
Organometallics
October 2024
School of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich, Norfolk NR1 1GE, United Kingdom.
This work presents the synthesis of five new functionalized (benz)imidazolium -heterocyclic (NHC) ligands () and four new (benz)imidazole silver(I) NHC (Ag(I)-NHC) complexes of mononuclear or binuclear type. The complexes have been fully characterized, including single crystal X-ray diffraction of three new structures. The complexes and their corresponding free NHC ligands have been screened against breast cancer and noncancerous cell lines, showing the mononuclear benzimidazole complex has the highest activity, while the binuclear benzimidazole complex has the highest cancer cell selectivity.
View Article and Find Full Text PDFReplacing imidazole with benz-imidazole: a promising approach to enhance the electrocatalytic performance of imidazolium based surface active ionic liquids for greener electrosynthesis.
Chem Commun (Camb)
August 2024
Department of Chemistry, University of Kashmir, Srinagar-190006, J&K, India.
We present the synthesis of a novel benzimidazolium-based surface active ionic liquid (SAIL), 3-dodecyl-1-3λ-benzo[]imidazole chloride, a SAIL with excellent surface activity and self-aggregation tendency whose aqueous micellar solutions offer exceptional solubilizing capacity and electrocatalytic performance for efficient electrocarboxylation of halocarbons.
View Article and Find Full Text PDFAldiminium and 1,2,3-triazolium dithiocarboxylate zwitterions derived from cyclic (alkyl)(amino) and mesoionic carbenes.
Beilstein J Org Chem
December 2023
Laboratory of Catalysis, MolSys Research Unit, Université de Liège, Institut de chimie organique (B6a), Allée du six août 13, 4000 Liège, Belgium.
The synthesis of zwitterionic dithiocarboxylate adducts was achieved by deprotonating various aldiminium or 1,2,3-triazolium salts with a strong base, followed by the nucleophilic addition of the in situ-generated cyclic (alkyl)(amino) or mesoionic carbenes (CAACs or MICs) onto carbon disulfide. Nine novel compounds were isolated and fully characterized by H and C NMR, FTIR, and HRMS techniques. Moreover, the molecular structures of two CAAC·CS and two MIC·CS betaines were determined by X-ray diffraction analysis.
View Article and Find Full Text PDFA comparative study on the design and application of new nano benzimidazolium gemini ionic liquids for curing interfacial properties of the crude oil-water system.
RSC Adv
May 2023
Faculty of Chemistry and Petroleum Science, Bu-Ali Sina University Hamedan 6517838695 Iran
Gemini surface active ionic liquids (GSAILs) are considered a new prosperous class of ionic liquids and recognized as high performance materials. The present study explores the capabilities of the newly synthesized GSAILs, constructed from two benzimidazole rings attached a four or a six carbon spacer, namely [Cbenzim-C-benzimC][Br], = 4 and 6. The products were characterized with FT-IR, NMR, XRD, TGA, DTG and SEM methods and were used in curing interfacial properties of the crude oil-water system.
View Article and Find Full Text PDFConformal Imidazolium 1D Perovskite Capping Layer Stabilized 3D Perovskite Films for Efficient Solar Modules.
Adv Sci (Weinh)
December 2022
Pen-Tung Sah Institute of Micro-Nano Science and Technology, Jiujiang Research Institute, National & Local Joint Engineering Research Center of Preparation Technology of Nanomaterials, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
Although the perovskite solar cells have been developed rapidly, the industrialization of perovskite photovoltaics is still facing challenges, especially considering their stability issues. Here, the new type of benzimidazolium salt, N,N'-dialkylbenzimidazolium iodide, is proposed and functionalized to convert the three-dimensional (3D) FACs-perovskite films into one-dimensional (1D) capping layer topped 1D/3D structure either in individual device or module levels. This conformal interface modulation demonstrates that not only can effectively stabilize FACs-based perovskite films by inhibiting the lateral and vertical iodide diffusions in devices or modules, ensuring an excellent operation and environmental stability, but also provides an excellent charge transporting channel through the well-designed 1D crystal structure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!