Pralidoxime and pesticide poisoning: A question of severity?

Biomed J

Staff Writer at the Biomedical Journal, 56 Dronningens Gate, 7012 Trondheim, Norway. Electronic address:

Published: December 2016

In this issue of the Biomedical Journal, we highlight new data supporting the use of pralidoxime in the treatment of cases of organophosphate poisoning, which also suggest that WHO treatment guidelines should be updated. We also learn about a modified surgical technique to repair severe spinal injuries, as well as new insight into the structure of human adenovirus that could inform vaccine development.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138517PMC
http://dx.doi.org/10.1016/j.bj.2016.12.001DOI Listing

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Farmers from South Asian countries spray insecticides without protective gear, which leads to insecticide exposure through dermal and nasal routes. Acetylcholinesterase plays a crucial role in controlling neuromuscular function. Organophosphate and carbamate insecticides inhibit acetylcholinesterase, which leads to severe neuronal/cognitive dysfunction, breathing disorders, loss of endurance, and death.

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