AI Article Synopsis
- Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) impact over 1 billion people yearly, causing significant mortality and long-term health issues.
- Current treatments for NTDs face challenges like drug resistance, severe side effects, and complex administration, highlighting an urgent need for better solutions.
- This review emphasizes the untapped potential of natural products from plants, marine sources, and microbes as possible drug candidates for treating NTDs, focusing on four major diseases: human African trypanosomiasis, leishmaniasis, schistosomiasis, and lymphatic filariasis.
Article Abstract
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures. Natural products have been a valuable source of drug regimens that form the cornerstone of modern pharmaceutical care. In this review, we highlight the potential that remains untapped in natural products as drug leads for NTDs. We cover natural products from plant, marine, and microbial sources including natural-product-inspired semi-synthetic derivatives which have been evaluated against the various causative agents of NTDs. Our coverage is limited to four major NTDs which include human African trypanosomiasis (sleeping sickness), leishmaniasis, schistosomiasis and lymphatic filariasis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155950 | PMC |
| http://dx.doi.org/10.3390/molecules22010058 | DOI Listing |
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