AI Article Synopsis
- Researchers developed hollow nanocapsules for the delivery of doxorubicin (DOX) that respond to changes in both pH and redox conditions by stabilizing polymer vesicles through disulfide bonds.
- The nanocapsules showed slow release of DOX in an extracellular environment due to a cationic membrane that created an electrostatic barrier, but they released DOX quickly once inside the cell where glutathione concentration is higher.
- The nanocapsules effectively transported DOX into the cytoplasm and demonstrated significant anticancer effects on HeLa cells in laboratory tests.
Article Abstract
For the delivery of doxorubicin (DOX), pH and redox dual responsive hollow nanocapsules were prepared through the stabilization of polymer vesicles, which spontaneously formed from polyamidoamine dendron-poly(l-lysine) (PAMAM dendron-PLL), by the introduction of disulfide (SS) bonds between PLLs. The SS-bonded nanocapsules exhibited a very slow release of DOX under an extracellular environment because the cationic PLL membrane acted as an electrostatic barrier against the protonated DOX molecules. However, increasing the glutathione concentration to the intracellular level facilitated the immediate release of DOX through the collapse of nanocapsules by the spontaneous cleavage of SS bonds. SS-bonded nanocapsules also escaped from the endosome by the buffering effect of PAMAM dendrons, and DOX delivery into the cytoplasm was achieved. Furthermore, DOX molecules delivered by SS-bonded nanocapsules exhibited an effective in vitro anticancer effect to HeLa cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374370 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics9010004 | DOI Listing |
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