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Costing of Paediatric Treatment alongside Clinical Trials under Low Resource Constraint Environments: Cotrimoxazole and Antiretroviral Medications in Children Living with HIV/AIDS. | LitMetric

AI Article Synopsis

  • Costing evidence is crucial for policymakers to make informed decisions about prioritizing healthcare resources and budget allocation, particularly highlighted by clinical trials of ARVs and cotrimoxazole.
  • A micro-based costing approach was utilized to gather data on patient costs, using case record forms and various pricing indicators to accurately allocate expenses for medication, human resources, and other necessities.
  • Significant cost disparities were identified between cotrimoxazole and ARV treatments, with average costs showing that cotrimoxazole treatment is more expensive due to factors like higher human resource demands, increased infections, and longer hospital stays.

Article Abstract

. Costing evidence is essential for policy makers for priority setting and resource allocation. It is in this context that the clinical trials of ARVs and cotrimoxazole provided a costing component to provide evidence for budgeting and resource needs alongside the clinical efficacy studies. . A micro based costing approach was adopted, using case record forms for maintaining patient records. Costs for fixed assets were allocated based on the paediatric space. Medication and other resource costs were costed using the WHO/MSH Drug Price Indicators as well as procurement data where these were available. . The costs for cotrimoxazole and ARVs are significantly different. The average costs for human resources were US$22 and US$71 for physician costs and $1.3 and $16 for nursing costs while in-patient costs were $257 and $15 for the cotrimoxazole and ARV cohorts, respectively. Mean or average costs were $870 for the cotrimoxazole cohort and $218 for the ARV. The causal factors for the significant cost differences are attributable to the higher human resource time, higher infections of opportunistic conditions, and longer and higher frequency of hospitalisations, among others.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153543PMC
http://dx.doi.org/10.1155/2016/9456906DOI Listing

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