AI Article Synopsis

  • Conserved non-coding sequences (CNSs) in Eukaryotes are important for regulation and vary in their abundance, sequence, and location across different lineages.
  • The study analyzed CNSs from 24 fungi, 19 invertebrates, and 12 non-mammalian vertebrates, revealing that fungi and invertebrate CNSs are mostly GC-rich, while vertebrate CNSs are GC-poor.
  • This transition from GC-rich to GC-poor content in vertebrates suggests a lineage-specific evolution influenced by transcription factor binding sites, and this GC content is related to how nucleosomes occupy and structure DNA.

Article Abstract

Conserved non-coding sequences (CNSs) of Eukaryotes are known to be significantly enriched in regulatory sequences. CNSs of diverse lineages follow different patterns in abundance, sequence composition, and location. Here, we report a thorough analysis of CNSs in diverse groups of Eukaryotes with respect to GC content heterogeneity. We examined 24 fungi, 19 invertebrates, and 12 non-mammalian vertebrates so as to find lineage specific features of CNSs. We found that fungi and invertebrate CNSs are predominantly GC rich as in plants we previously observed, whereas vertebrate CNSs are GC poor. This result suggests that the CNS GC content transition occurred from the ancestral GC rich state of Eukaryotes to GC poor in the vertebrate lineage due to the enrollment of GC poor transcription factor binding sites that are lineage specific. CNS GC content is closely linked with the nucleosome occupancy that determines the location and structural architecture of DNAs.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203776PMC
http://dx.doi.org/10.1093/gbe/evw231DOI Listing

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