The resolution of any spectroscopic or interferometric experiment is ultimately limited by the total time a particle is interrogated. Here we demonstrate the first molecular fountain, a development which permits hitherto unattainably long interrogation times with molecules. In our experiments, ammonia molecules are decelerated and cooled using electric fields, launched upwards with a velocity between 1.4 and 1.9 m/s and observed as they fall back under gravity. A combination of quadrupole lenses and bunching elements is used to shape the beam such that it has a large position spread and a small velocity spread (corresponding to a transverse temperature of <10 μK and a longitudinal temperature of <1 μK) when the molecules are in free fall, while being strongly focused at the detection region. The molecules are in free fall for up to 266 ms, making it possible, in principle, to perform sub-Hz measurements in molecular systems and paving the way for stringent tests of fundamental physics theories.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1103/PhysRevLett.117.253201 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Computational modeling design of novel NMDAR agonist for the treatment of Schizophrenia.
Neurogenetics
January 2025
Department of Biochemistry, College of Medicine, University of Lagos, Lagos State, Nigeria.
Schizophrenia (SZ) is a complex, chronic mental disorder characterized by positive symptoms (such as delusions and hallucinations), negative symptoms (including anhedonia, alogia, avolition, and social withdrawal), and cognitive deficits (affecting attention, processing speed, verbal and visuospatial learning, problem-solving, working memory, and mental flexibility). Extensive animal and clinical studies have emphasized the NMDAR hypofunction hypothesis of SZ. Glycine plays a crucial role as an agonist of NMDAR, enhancing the receptor's affinity for glutamate and supporting normal synaptic function and plasticity, that is, signal transmission between neurons.
View Article and Find Full Text PDFPromoter capture Hi-C identifies promoter-related loops and fountain structures in Arabidopsis.
Genome Biol
December 2024
State Key Laboratory of Protein and Plant Gene Research, School of Advanced Agricultural Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China.
Background: Promoters serve as key elements in the regulation of gene transcription. In mammals, loop interactions between promoters and enhancers increase the complexity of the promoter-based regulatory networks. However, the identification of enhancer-promoter or promoter-related loops in Arabidopsis remains incomplete.
View Article and Find Full Text PDFMRI findings in six dogs with ependymoma of the brain and spinal cord.
Vet Radiol Ultrasound
January 2025
Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania School of Veterinary Medicine, Section of Radiology, Philadelphia, Pennsylvania, USA.
There are few published descriptions of the MRI appearance of canine intracranial or spinal cord ependymoma. In this multicenter, retrospective, secondary analysis, case series study, three veterinary radiologists independently reviewed and recorded imaging characteristics of MRI studies in six dogs with histopathologically confirmed ependymoma (three intracranial and three spinal cord cases). A consensus was reached when there was disagreement on specific features.
View Article and Find Full Text PDFPerformance prediction of polypeptide derivatives as efficient potential microbial inhibitors: a computational approach.
Int J Biochem Mol Biol
October 2024
Department of Industrial Chemistry, Bowen University PMB 284, Iwo, Osun State, Nigeria.
Objective: Lately, various scientists have been paying a lot of consideration to the design of operational antimicrobial agents due to the rise of multiple drug-resistant strains. Therefore, this work is aimed at discovering the biochemical behavior of the analyzed polypeptides in relation to glutamine amidotransferase GatD (pdb id: 5n9m) for gram positive bacteria and beta-lactamase class A (pdb id: 5fqq) for gram negative bacteria. Additionally, this study aims to identify the specific atoms involved in the observed biochemical interactions between the studied complexes using computational methods.
View Article and Find Full Text PDFChromatin remodeller Chd7 is developmentally regulated in the neural crest by tissue-specific transcription factors.
PLoS Biol
October 2024
Stowers Institute for Medical Research, Kansas City, Missouri, United States of America.
Article Synopsis
- Neurocristopathies like CHARGE syndrome are linked to abnormal development of neural crest cells, mainly due to genetic mutations in the CHD7 gene, which is crucial for chromatin remodeling.
- Researchers used epigenomic profiling of neural crest cells in chick and human models to identify enhancers that control the expression of CHD7.
- The study established connections between transcription factors and enhancers specific to neural crest cells, highlighting the gene's role in a broader regulatory network and providing insights for better understanding CHARGE syndrome cases.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!