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Poly-functional and long-lasting anticancer immune response elicited by a safe attenuated vector for antigens delivery. | LitMetric

Poly-functional and long-lasting anticancer immune response elicited by a safe attenuated vector for antigens delivery.

Mol Ther Oncolytics

Laboratoire TIMC-TheREx UMR 5525 CNRS-Université Grenoble Alpes, La Tronche, France; Département de Biochimie Toxicologie Pharmacologie, UM Biochimie des Enzymes et des Protéines, Institut de Biologie et Pathologie, C.H.U. de Grenoble, Grenoble, France.

Published: December 2016

AI Article Synopsis

  • Live-attenuated bacterial vectors are being explored as a way to deliver antigens for cancer immunotherapy, enhancing the immune response against tumors.
  • Researchers have developed genetically modified, safe bacteria that can introduce protein antigens into immune cells, showing effectiveness in protecting mice from aggressive melanoma in both preventative and treatment scenarios.
  • The study found that immunizing with these inactive yet metabolically active vectors results in a strong and lasting CD8 T cell response, leading to increased protection against tumors through the formation of memory immune cells.

Article Abstract

Live-attenuated bacterial vectors for antigens delivery have aroused growing interest in the field of cancer immunotherapy. Their potency to stimulate innate immunity and to promote intracellular antigen delivery into antigen-presenting cells could be exploited to elicit a strong and specific cellular immune response against tumor cells. We previously described genetically-modified and attenuated vectors able to deliver protein antigens into antigen-presenting cells, through Type 3 secretion system of the bacteria. Using this approach, we managed to protect immunized mice against aggressive B16 melanoma development in both a prophylactic and therapeutic setting. In this study, we further investigated the antigen-specific CD8 T cell response, in terms of phenotypic and functional aspects, obtained after immunizations with a killed but metabolically active attenuated vector. We demonstrated that vaccine induces a highly functional pool of antigen-specific CD8+ T cell able to infiltrate the tumor. Furthermore, multiple immunizations allowed the development of a long-lasting immune response, represented by a pool of predominantly effector memory cells which protected mice against late tumor challenge. Overall, killed but metabolically active vector is a safe and promising approach for active and specific antitumor immunotherapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155632PMC
http://dx.doi.org/10.1038/mto.2016.33DOI Listing

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