AI Article Synopsis
- Hepatitis B and C viruses can evade the immune system and lead to chronic liver damage.
- Regulatory T (Treg) cells help manage the immune response during these infections, potentially reducing inflammation and liver injury.
- This review emphasizes the importance of Treg cells in moderating immune responses against HBV and HCV.
Article Abstract
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish chronic persistent infection by effectively escaping the host immune response and can cause immune-mediated liver injury. It has recently become apparent that regulatory T (Treg) cells, specifically CD4CD25Foxp3 Treg cells, modulate viral diseases by suppressing antiviral immune responses and regulating inflammatory host injury. The roles of Treg cells in HBV and HCV infections range from suppressing antiviral T cell responses to protecting the liver from immune-mediated damage. This review describes Treg cells and subpopulations and focuses on the roles of these cells in HBV and HCV infections.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195842 | PMC |
| http://dx.doi.org/10.4110/in.2016.16.6.330 | DOI Listing |
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