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Antibodies to thrombomodulin are found in patients with lupus anticoagulant and unexplained thrombosis.
J Rheumatol
February 2000
Oklahoma Medical Research Foundation, Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA.
Objective: To test the hypothesis that thrombomodulin (TM) may be a target for lupus anticoagulant (LAC) antibodies.
Methods: A recombinant soluble form of TM was produced and used as an antigen for an ELISA to detect antibodies to TM (TMAB). Sixty-one samples from 58 patients identified by the coagulation laboratory as having a LAC and 200 patients with unexplained thrombosis were evaluated along with 201 healthy controls.
On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies.
J Clin Invest
January 1995
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104.
Phosphatidylethanolamine (PE) is an important membrane component for supporting activated protein C anticoagulant activity but has little influence on prothrombin activation. This difference constitutes a potential mechanism for selective inhibition of the protein C anticoagulant pathway by lupus anticoagulants and/or antiphospholipid antibodies. In this study, we demonstrate that the presence of PE augments lupus anticoagulant activity.
View Article and Find Full Text PDFThe natural anticoagulant protein S is decreased in male smokers.
Am Heart J
July 1991
Cardiology Division, University of Iowa.
Protein S is a natural anticoagulant plasma protein; familial deficiency is associated with thrombotic complications. Since smoking carries an increased risk of myocardial infarction and stroke, we investigated the protein S system of men who smoke. In plasma, free protein S is functionally active and protein S bound to C4b binding protein is inactive.
View Article and Find Full Text PDFAcquired deficiencies of protein S. Protein S activity during oral anticoagulation, in liver disease, and in disseminated intravascular coagulation.
J Clin Invest
May 1988
Cardiovascular/Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104.
Protein S is a vitamin K-dependent plasma protein which serves as the cofactor for activated protein C. Protein S circulates in both an active, free form and in an inactive complex with C4b-binding protein. To elucidate the role of protein S in disease states and during oral anticoagulation, we developed a functional assay for protein S that permits evaluation of the distribution of protein S between free and bound forms and permits determination of the specific activity of the free protein S.
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