The application of centrifugal pumps as heart assist devices imposes design limitations on the impeller geometry. Geometry and operating parameters will affect the performance and the hemocompatibility of the device. Among all the parameters affecting the hemocompatibility, pressure, rotational speed, blade numbers, angle, and width have significant impact on the blood trauma. These parameters directly (pressure, speed) and indirectly (geometry) affect the efficiency of the pump as well. This study describes the experimental investigation on geometric parameters and their effect on the performance of small centrifugal pumps suitable for Mechanical Circulatory Support (MCS) devices. Experimental and numerical techniques were implemented to analyze the performance of 15 centrifugal impellers with different characteristics. The effect of each parameter on the pump performance and hemolysis was studied by calculating the normalized index of hemolysis (NIH) and the shear stress induced in each pump. The results show five and six blades, 15-35° outlet angle, and the lowest outlet width that meets the required pressure rise are optimum values for an efficient hemocompatible pump.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/MAT.0000000000000457 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative Analysis of In Vitro Pumps Used in Cardiovascular Investigations: Focus on Flow Generation Principles and Characteristics of Generated Flows.
Bioengineering (Basel)
November 2024
Biomedical Research Center, Qatar University, Doha 2713, Qatar.
A comprehensive analysis of in vitro pumps used in cardiovascular research is provided in this review, with a focus on the characteristics of generated flows and principles of flow generations. The cardiovascular system, vital for nutrient circulation and waste removal, generates complex hemodynamics critical for endothelial cell function. Cardiovascular diseases (CVDs) could be caused by the disturbances in these flows, including aneurysms, atherosclerosis, and heart defects.
View Article and Find Full Text PDFHuman milk feeding practices and serum immune profiles of one-year-old infants in the CHILD birth cohort study.
Am J Clin Nutr
October 2024
Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada; Manitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:
Article Synopsis
- This study explored the relationship between current human milk feeding (HMF) and infant immune biomarker profiles in a cohort of 605 infants from Canada.
- Results indicated that infants currently receiving HMF had higher levels of specific immune-related biomarkers compared to those who weren't.
- The findings suggest that HMF status is important for immune development, but the duration and exclusivity of HMF did not significantly correlate with the biomarkers measured.
Effect of Blade Thickness on Hemodynamics and Hemolysis: A Case Study of Pediatric Centrifugal Blood Pumps.
J Biomech Eng
February 2025
Arts et Métiers Institute of Technology, CNAM, LIFSE, Paris F-75013, France.
Blood pumps, critical components in ventricular assist devices and extracorporeal membrane oxygenation systems, are primarily evaluated based on their ability to minimize blood damage through optimized design. Despite extensive research, the impact of impeller blade thickness and the proximity of rotating and stationary surfaces remains insufficiently explored. This study presents a comprehensive analysis, combining experimentally validated numerical simulations with an advanced Lagrangian approach, to compare the hemodynamic and hemolytic performance of three centrifugal pumps.
View Article and Find Full Text PDFMicrofluidic methods for the diagnosis of acute respiratory tract infections.
Analyst
December 2024
Life Sciences Division, Medical Devices Research Centre, National Research Council of Canada, 75 de Mortagne Boulevard, Boucherville, QC, J4B 6Y4, Canada.
Acute respiratory tract infections (ARTIs) are caused by sporadic or pandemic outbreaks of viral or bacterial pathogens, and continue to be a considerable socioeconomic burden for both developing and industrialized countries alike. Diagnostic methods and technologies serving as the cornerstone for disease management, epidemiological tracking, and public health interventions are evolving continuously to keep up with the demand for higher sensitivity, specificity and analytical throughput. Microfluidics is becoming a key technology in these developments as it allows for integrating, miniaturizing and automating bioanalytical assays at an unprecedented scale, reducing sample and reagent consumption and improving diagnostic performance in terms of sensitivity, throughput and response time.
View Article and Find Full Text PDFA Novel Size-Based Centrifugal Microfluidic Design to Enrich and Magnetically Isolate Circulating Tumor Cells from Blood Cells through Biocompatible Magnetite-Arginine Nanoparticles.
Sensors (Basel)
September 2024
Department of Mechanical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK S7N 5A9, Canada.
This paper presents a novel centrifugal microfluidic approach (so-called lab-on-a-CD) for magnetic circulating tumor cell (CTC) separation from the other healthy cells according to their physical and acquired chemical properties. This study enhances the efficiency of CTC isolation, crucial for cancer diagnosis, prognosis, and therapy. CTCs are cells that break away from primary tumors and travel through the bloodstream; however, isolating CTCs from blood cells is difficult due to their low numbers and diverse characteristics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!