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Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View. | LitMetric

Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View.

Chembiochem

Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT, 84113, USA.

Published: May 2017

AI Article Synopsis

Article Abstract

DNA-encoded chemical libraries (DECLs) are pools of DNA-tagged small molecules that enable facile screening and identification of bio-macromolecule binders. The successful development of DECLs has led to their increasingly important role in drug development, and screening hits have entered clinical trials. In this review, we summarize the development and currently active research areas of DECLs with a focus on contributions from groups at academic institutes. We further look at opportunities and future directions of DECL research in medicinal chemistry and chemical biology based on the symbiotic relationship between academia and industry. Challenges associated with the application of DECLs in academic drug discovery are further discussed.

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Source
http://dx.doi.org/10.1002/cbic.201600567DOI Listing

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