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IL-34 aggravates myocardial ischemia-reperfusion injury by upregulating the HMGB1-IL-17A-IL-6 axis through the JAK signaling pathway.
PLoS One
January 2025
Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, PR China.
Interleukin-34 (IL-34) was recently reported to be a new biomarker for atherosclerosis diseases, such as coronary artery disease and vascular dementia. IL-34 regulates the expression of proinflammatory cytokines (IL-17A, IL-1 and IL-6), which are classical cytokines involved in myocardial ischemia‒reperfusion (MI/R) injury. However, the exact role of IL-34 in MI/R remains unknown.
View Article and Find Full Text PDFDiagnosis and Management of Acute Coronary Syndrome Patients Without Obstructive Epicardial Stenosis.
Curr Cardiol Rep
January 2025
Division of Cardiology, Louisiana State University Health Sciences Center - Shreveport (LSUHSC-S), 1501 Kings Hwy, Shreveport, LA, 71103, USA.
Purpose Of Review: What is the pathophysiology and clinical findings as well as management of patients presenting with INOCA/MINOCA (Ischemia/Myocardial Infarction with Non-Obstructive Coronary Arteries).
Recent Findings: INOCA/MINOCA has a complex pathophysiology. In this review article, we aim to summarize the complex pathophysiology and clinical diagnosis, and review the current management options.
Longitudinal study on 3D ultrasound-based rupture risk assessment of Abdominal Aortic Aneurysms.
Eur Heart J Cardiovasc Imaging
January 2025
PULS/e group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Aims: Image-based, patient-specific rupture risk analysis of AAAs is promising but it is limited by invasive and costly imaging modalities. Ultrasound (US) offers a safe, more affordable alternative, allowing multiple assessments during follow-up and enabling longitudinal studies on AAA rupture risk.
Methods And Results: This study used time-resolved three-dimensional US to assess AAA rupture risk parameters over time, based on vessel and intraluminal thrombus (ILT) geometry.
Multivalvular vs single-valve infective endocarditis: a systematic review and meta-analysis.
Future Cardiol
January 2025
Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA.
Background: Infective endocarditis is characterized by the colonization of heart valves by virulent microorganisms. It commonly manifests as involvement of a single heart valve -single-valve infective endocarditis (SIE), while in some patients, two or more heart valves are concomitantly infected -multivalvular infective endocarditis (MIE). The risk of complications and prognosis of MIE as opposed to SIE are unknown.
View Article and Find Full Text PDFComparison of ultrasound-assisted thrombolysis and mechanical thrombectomy in intermediate-high-risk pulmonary embolism.
Vasa
January 2025
Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, University of Duisburg-Essen, Essen, Germany.
Pulmonary embolism (PE) can result in high mortality. Early risk stratification and treatment are critical for individualized management. In patients with intermediate-high-risk (IHR) PE, guidelines recommend to consider a percutaneous catheter-directed treatment (CDT).
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