AI Article Synopsis
- The study examines how small genetic changes in protein tyrosine phosphatases (PTPs) relate to colorectal cancer, focusing on intragenic gains and losses.
- Researchers analyzed 25 PTP genes in 16 colorectal cancer samples using advanced genetic techniques, finding two significant small alterations in specific PTP genes.
- The findings indicate that while large chromosomal changes in PTPs are common in colorectal cancer, small intragenic changes are relatively rare, suggesting a unique genetic landscape for these proteins in the disease.
Article Abstract
Background/aim: Molecular mechanisms of alterations in protein tyrosine phosphatases (PTPs) genes in cancer have been previously described and include chromosomal aberrations, gene mutations, and epigenetic silencing. However, little is known about small intragenic gains and losses that may lead to either changes in expression or enzyme activity and even loss of protein function.
Materials And Methods: The aim of this study was to investigate 25 phosphatase genes using customized array comparative genomic hybridization in 16 sporadic colorectal cancer tissues.
Results: The analysis revealed two unique small alterations: of 2 kb in PTPN14 intron 1 and of 1 kb in PTPRJ intron 1. We also found gains and losses of whole PTPs gene sequences covered by large chromosome aberrations.
Conclusion: In our preliminary studies using high-resolution custom microarray we confirmed that PTPs are frequently subjected to whole-gene rearrangements in colorectal cancer, and we revealed that non-polymorphic intragenic changes are rare.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267501 | PMC |
| http://dx.doi.org/10.21873/cgp.20019 | DOI Listing |
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