AI Article Synopsis
Article Abstract
Objective To retrospectively determine the features of stones and calcifications in hepatobiliary system on virtual nonenhanced (VNE) dual-energy computed tomography (CT), and to evaluate the possibility of VNE images in diagnosis for those lesions.Methods A total of 128 gall stones and calcifications of the liver found in 110 patients were examined with triple phase abdominal CT scan from July 2007 to December 2011, in which true nonenhanced (TNE) phase and arterial phase were performed with single-energy CT (120 kVp) and portal venous phase was performed with dual-energy CT (100 kVp and 140 kVp). VNE images were generated from the portal venous phase dual-energy CT data sets by using commercially VNC software. The mean CT values for the stone, liver, bile and paraspinal muscle, mean lesion density and size in area dimension, contrast-to-noise ratio (CNR) of lesion to the liver or bile, and image noise were assessed and compared between VNE and TNE images. The effective dose and size-specific dose estimate (SSDE) were also calculated.Results The mean CT values of the lesions measured on VNE images declined significantly compared with those measured on TNE images (164.51±102.13 vs. 290.72±197.80 HU, P<0.001), so did the lesion-to-liver CNR (10.80±11.82 vs.18.81±17.06, P<0.001) and the lesion-to-bile CNR (17.24±14.41 vs. 21.32±17.31, P<0.001). There was no significant difference in size of lesions area between VNE and TNE images (0.69±0.88 vs. 0.72±0.85 cm, P=0.062). Compared to the 128 lesions found in TNE images, VNE images showed the same density in 30 (23.4%) lesions, lighter density in 88 (68.8%) lesions, while failed to show 10 (7.8%) lesions, and showed the same size in 61 (47.7%) lesions and smaller size in 57 (44.5%) lesions. The CT cutoff values of lesion and size were 229.21 HU and 0.15 cm, respectively. The total effective dose for triple phase scan protocol with TNE images was 19.51±7.03 mSv, and the SSDE was 39.84±11.10 mGy. The effective dose for dual phase scan protocol with VNE images instead of TNE images was 13.29±4.89 mSv, and the SSDE was 27.83±9.99 mGy. Compared with TNE images, the effective dose and SSDE of VNE images were down by 32.05%±3.69 % and 30.63%±2.34 %, respectively.Conclusions Although the CT values and CNR of the lesions decreased in VNE images, the lesions of which attenuation greater than 229.21 HU and size larger than 0.15 cm could be detected with good reliability and obvious dose reduction. There was good consistency in the size of stones and calcifications in hepatobiliary system between VNE images and TNE images, which ensured the possibility of the clinical application of VNE images.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s1001-9294(16)30029-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intraosseous Hemangioma of the Iliac Bone: An Incidental Finding Mimicking Metastatic Disease.
Cureus
November 2024
General Surgery, Northeast Georgia Medical Center Gainesville, Gainesville, USA.
Intraosseous hemangiomas are rare benign vascular tumors predominantly occurring in the axial skeleton. This case report describes a 44-year-old female with a history of multiple renal stones and benign breast calcifications, who was incidentally found to have a 1.2 cm lucent lesion in the left iliac bone during imaging for nephrolithiasis.
View Article and Find Full Text PDFAnnexin-derived self-assembling peptide nanostructures for alleviation of calcium oxalate -induced renal injury.
Urolithiasis
December 2024
Materials Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, India.
The formation of polycrystalline aggregates in the glomerulus or other components of the urinary system is indisputably the most critical step in the formation of kidney stones and calcium oxalate monohydrate (CaCO·HO) is the most prevalent form. On the other hand, Annexin A1 (ANXA1), a calcium-binding protein, markedly increased on the apical surface of renal cells in CaCO-induced nephrolithiasis. In this regard, we identified the peptide motif responsible for calcium binding and redesigned it into a self-assembling peptide sequence without disturbing its binding selectivity for the CaCO interface.
View Article and Find Full Text PDFChronic pancreatitis.
Lancet
December 2025
Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands.
Chronic pancreatitis is a progressive fibroinflammatory disease primarily caused by a complex interplay of environmental and genetic risk factors. It might result in pancreatic exocrine and endocrine insufficiency, chronic pain, reduced quality of life, and increased mortality. The diagnosis is based on the presence of typical symptoms and multiple morphological manifestations of the pancreas, including pancreatic duct stones and strictures, parenchymal calcifications, and pseudocysts.
View Article and Find Full Text PDFBringing down two Goliaths with one stone: Reducing lung cancer and cardiovascular mortality with low-dose CT screening.
Respirology
December 2024
Department of Respiratory Medicine, Austin Health, Heidelberg, Victoria, Australia.
Outcomes of coronary intravascular lithotripsy for the treatment of calcified nodules: a pooled analysis of the Disrupt CAD studies.
EuroIntervention
December 2024
St. Francis Hospital, Roslyn, NY, USA.
Article Synopsis
- Coronary intravascular lithotripsy (IVL) is an effective method for stent implantation in severely calcified lesions, specifically those with calcified nodules (CNs).
- In a study of 155 patients, IVL demonstrated similar outcomes in terms of stent area and expansion, regardless of the presence of CNs, even though CNs had higher calcium volume and angle.
- The 2-year rate of target lesion failure was not significantly different between CN and non-CN lesions, suggesting that further research is needed to evaluate different treatment methods for these types of lesions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!